... the entire Caenorhabditis elegans nervous system. Distinct, lineage-specific proneural class II bHLH factors are generally thought to operate via interaction with a common, class I bHLH subunit, encoded by Daughterless in flies, the E proteins in vertebrates and HLH-2 in C. elegans . To eliminate function...

... and E2f1 . Here, we show that, in addition to these mechanisms, some Notch signaling is devoted to blocking the growth-suppressing activity of the bHLH DNA-binding protein Daughterless (Da). We demonstrate that Notch signaling activates the expression of extramacrochaetae ( emc ), which encodes a helix...

... twist daughterless extra machrochaetae Enhancer of split Early in vertebrate and invertebrate development, uncommitted mesodermal cells are patterned into repetitive segments and allocated to specific tissue fates. In Drosophila , this process of segmentation and patterning first...

... provide evidence that wingless mediates both effects, at least in part, through repression of the basic helix-loop-helix protein Daughterless. daughterless is required for high proneural gene expression and furrow progression. Ectopic expression of wingless blocks Daughterless expression in the proneural...

...John E. Smith, III; Craig A. Cummings; Claire Cronmiller During Drosophila oogenesis two distinct stem cell populations produce either germline cysts or the somatic cells that surround each cyst and separate each formed follicle. From analyzing daughterless (da) loss-of-function, overexpression...

...John E. Smith, III; Claire Cronmiller As the only class I helix-loop-helix transcription factor in Drosophila , Daughterless (Da) has generally been regarded as a ubiquitously expressed binding partner for other developmentally regulated bHLH transcription factors. From analysis of a novel tissue...

... choice. We find that Twist can form homodimers and heterodimers with the Drosophila E protein homologue, Daughterless,in vitro. Using tethered dimers to assess directly the function of these two particular dimers in vivo, we show that Twist homodimers specify mesoderm and the subsequent allocation...

...Michael Krause; Morgan Park; Jian-Ming Zhang; Jeff Yuan; Brian Harfe; Si-Qun Xu; Iva Greenwald; Michael Cole; Bruce Paterson; Andrew Fire ABSTRACT The E proteins of mammals, and the related Daughterless (DA) protein of Drosophila , are ubiquitously expressed helix-loop-helix (HLH) transcription...

... and requires proneural and neurogenic genes. In neurogenic mutants the principle midgut epithelial cells are missing and the other two cell types develop in great excess. Consequently, the midgut epithelium does not form. In achaete-scute complex and daughterless mutants the interstitial cell precursors do...

... ), scute ( sc ) and lethal of scute ( l’sc )) and daughterless ( da ). The da protein dimerizes with AS-C products in vitro to form DNA-binding proteins. Previous studies have shown that the AS-C genes are expressed initially in discrete clusters of ectodermal cells (the proneural clusters) and then more...

...Craig A. Cummings; Claire Cronmiller ABSTRACT The daughterless ( da ) gene in Drosophila encodes a broadly expressed transcriptional regulator whose specific functions in the control of sex determination and neurogenesis have been extensively examined. We describe here a third major developmental...