...Wesley L. Hung; Ying Wang; Jyothsna Chitturi; Mei Zhen Adverse environmental conditions trigger C. elegans larvae to activate an alternative developmental program, termed dauer diapause, which renders them stress resistant. High-level insulin signaling prevents constitutive dauer formation. However...

...Akira Ogawa; Gilberto Bento; Gabi Bartelmes; Christoph Dieterich; Ralf J. Sommer The nematode Pristionchus pacificus shows two forms of phenotypic plasticity: dauer formation and dimorphism of mouth form morphologies. It can therefore serve as a model for studying the evolutionary mechanisms...

... larva at the end of the second larval stage. Here, we show that the period homolog lin-42 , known to control developmental time, also acts as a component of a switch that mediates dauer entry. Loss of lin-42 function renders animals hypersensitive to dauer formation under stressful conditions, whereas...

... Smad in vivo and in vitro. Overexpression of daf-8 conferred a dauer-defective phenotype and suppressed constitutive dauer formation in daf-8 and daf-14 mutants. In contrast to mammalian systems described thus far, active DAF-3 drives a feedback regulatory loop that represses transcription of daf-7...

... that govern dauer formation and reproduction in C. elegans. Cell 124 , 1209 -1223. Nanji, M., Hopper, N. A. and Gems, D. ( 2005 ). LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans. Aging Cell 4 , 235 -245. Nicholas, H. R. and Hodgkin, J...

... and life span. * Author for correspondence (e-mail: [email protected] ) 6 5 2004 ©2004. 2004 TOR Raptor daf-15 Dauer formation Aging Insulin In multicellular organisms, the control of growth depends on the integration of genetic and environmental cues( Conlon...

... is not affected by the duration of the dauer stage ( Klass, 1976 ). *Author for correspondence (e-mail: [email protected] ) 11 10 2001 © 2002. 2002 Cytochrome P450 Dauer formation Aging daf-9 daf-12 TGF-β Insulin Fig. 1. daf-9 mutant phenotype. (A) C. elegans...