... of rod bipolar cells, cone photoreceptors and Muller glia. Our data indicate that sustained RELN/DAB1 signaling, triggered by depletion of RBX2 or SOCS7 – a CRL5 substrate adaptor known to recruit DAB1 – causes rod bipolar cell misposition. Moreover, whereas SOCS7 also controls Muller glia cell...

...Elvira Khialeeva; Timothy F. Lane; Ellen M. Carpenter Reelin signaling is required for appropriate cell migration and ductal patterning during mammary gland morphogenesis. Dab1, an intracellular adaptor protein activated in response to reelin signaling, is expressed in the developing mammary bud...

... process, while the reelin intracellular effector Dab1 was expressed by cell groups that included the two populations affected. Mice mutant at the Dab1 locus, called scrambler , exhibit the same phenotype, a failure of final migration. However, examination of mice lacking both reelin receptors, ApoER2...

... further demonstrate that this signaling requires Dab1, as the increase in Blbp upon reelin addition failed to occur in Dab1 -/- mice. Taken together, these results unravel a novel role of reelin signaling to radial glial cells that is crucial for the regulation of their Blbp content and characteristic...