... signaling in the process of apical constriction during Xenopus gastrulation. The core PCP protein Vangl2 is detected at the apical surfaces of cells at the blastopore lip, and it functions during blastopore formation and closure. Further experiments show that Vangl2, as well as Daam1 and Rho-associated...

.... 1F ), and continued throughout larval ( Fig. 1G ) and juvenile ( Fig. 1H ) stages into adulthood (data not shown). In the larvae, daam1a mRNA localised to the asymmetric habenular neuropil ( Fig. 1G ). Whole-mount immunofluorescence (using an antibody directed against human DAAM1 that also detects...

... signaling pathway in neural tube closure, the underlying mechanism remains poorly resolved. Here, we show that the missing in metastasis (MIM; Mtss1) protein, previously identified as a Hedgehog response gene and actin and membrane remodeling protein, specifically binds to Daam1 and couples non-canonical...

...Deqiang Li; Mark A. Hallett; Wuqiang Zhu; Michael Rubart; Ying Liu; Zhenyun Yang; Hanying Chen; Laura S. Haneline; Rebecca J. Chan; Robert J. Schwartz; Loren J. Field; Simon J. Atkinson; Weinian Shou Dishevelled-associated activator of morphogenesis 1 (Daam1), a member of the formin protein family...

... modification of the actin cytoskeleton remain incompletely understood. We had previously identified the Formin homology protein Daam1 as an important link between Dishevelled and the Rho GTPase for cytoskeletal modulation. Here, we report that Profilin1 is an effector downstream of Daam1 required...