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Keywords: DOT1L
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Journal Articles

DOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement

Open Access
Aushaq B. Malla, Shannon R. Rainsford, Zachary D. Smith, Bluma J. Lesch
Journal: Development
Development (2023) 150 (9): dev201497.
https://doi.org/10.1242/dev.201497
Published: 12 May 2023
... be executed correctly to avoid sperm DNA damage, embryonic lethality and male sterility. Here, we define an essential role for the histone methyltransferase DOT1L in the histone-to-protamine transition. We show that DOT1L is abundantly expressed in mouse meiotic and postmeiotic germ cells...
View articletitled, DOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement
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Includes: Supplementary data
Journal Articles

The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis

Free
Huijuan Lin, Isabella G. Cossu, N. Adrian Leu, Aniruddha J. Deshpande, Kathrin M. Bernt, Mengcheng Luo, P. Jeremy Wang
Journal: Development
Development (2023) 150 (9): dev201501.
https://doi.org/10.1242/dev.201501
Published: 12 May 2023
...Huijuan Lin; Isabella G. Cossu; N. Adrian Leu; Aniruddha J. Deshpande; Kathrin M. Bernt; Mengcheng Luo; P. Jeremy Wang ABSTRACT Histone modifications regulate chromatin remodeling and gene expression in development and diseases. DOT1L, the sole histone H3K79 methyltransferase, is essential...
View articletitled, The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis
Open the PDF for The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis in another window
Includes: Supplementary data