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Keywords: DOT1L
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Journal Articles
The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis
Huijuan Lin, Isabella G. Cossu, N. Adrian Leu, Aniruddha J. Deshpande, Kathrin M. Bernt, Mengcheng Luo, P. Jeremy Wang
Journal:
Development
Development (2023) 150 (9): dev201501.
Published: 12 May 2023
...Huijuan Lin; Isabella G. Cossu; N. Adrian Leu; Aniruddha J. Deshpande; Kathrin M. Bernt; Mengcheng Luo; P. Jeremy Wang ABSTRACT Histone modifications regulate chromatin remodeling and gene expression in development and diseases. DOT1L, the sole histone H3K79 methyltransferase, is essential...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2023) 150 (9): dev201497.
Published: 12 May 2023
... be executed correctly to avoid sperm DNA damage, embryonic lethality and male sterility. Here, we define an essential role for the histone methyltransferase DOT1L in the histone-to-protamine transition. We show that DOT1L is abundantly expressed in mouse meiotic and postmeiotic germ cells...
Includes: Supplementary data