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Keywords: DOT1L
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Journal Articles
Journal: Development
Development (2023) 150 (9): dev201497.
Published: 12 May 2023
... be executed correctly to avoid sperm DNA damage, embryonic lethality and male sterility. Here, we define an essential role for the histone methyltransferase DOT1L in the histone-to-protamine transition. We show that DOT1L is abundantly expressed in mouse meiotic and postmeiotic germ cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (9): dev201501.
Published: 12 May 2023
...Huijuan Lin; Isabella G. Cossu; N. Adrian Leu; Aniruddha J. Deshpande; Kathrin M. Bernt; Mengcheng Luo; P. Jeremy Wang ABSTRACT Histone modifications regulate chromatin remodeling and gene expression in development and diseases. DOT1L, the sole histone H3K79 methyltransferase, is essential...
Includes: Supplementary data