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Keywords: DNA-methylation
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Journal Articles

The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons

Michelle K. Y. Seah, Yaju Wang, Pierre-Alexis Goy, Hui Mun Loh, Wen Jun Peh, Diana H. P. Low, Brenda Y. Han, Esther Wong, Ei Leen Leong, Gernot Wolf, Slim Mzoughi, Heike Wollmann, Todd S. Macfarlan, Ernesto Guccione, Daniel M. Messerschmidt
Journal: Development
Development (2019) 146 (19): dev170266.
https://doi.org/10.1242/dev.170266
Published: 10 July 2019
...: ZFP708. It recruits the repressive TRIM28 complex to RMER19B retrotransposons to evoke regional heterochromatin formation. ZFP708 binding to these hitherto unknown TRIM28 targets is DNA methylation and H3K9me3 independent. ZFP708 mutant mice are viable and fertile, yet embryos fail to inherit...
View articletitled, The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons
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Includes: Supplementary data