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Keywords: DNA methylation
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Journal Articles
Journal: Development
Development (2022) 149 (24): dev182683.
Published: 15 December 2022
...Alex Wei; Hao Wu ABSTRACT DNA methylation is a highly conserved epigenetic modification that plays essential roles in mammalian gene regulation, genome stability and development. Despite being primarily considered a stable and heritable epigenetic silencing mechanism at heterochromatic...
Journal Articles
Journal: Development
Development (2022) 149 (10): dev200390.
Published: 25 May 2022
... in zebrafish, and determined that DNA methyltransferase 1 (Dnmt1) is essential for HSPC generation via repression of Notch signaling. Depletion of dnmt1 resulted in decreased DNA methylation levels and impaired HSPC production. Mechanistically, we found that loss of dnmt1 induced hypomethylation of Notch genes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (13): dev199492.
Published: 6 July 2021
... deficiency impacts male fertility and sperm DNA methylation, there is the potential for epimutations to be passed to the next generation. Here, we assessed whether the impact of MTHFR deficiency on testis morphology and sperm DNA methylation is exacerbated across generations in mouse. Although MTHFR...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (10): dev194605.
Published: 17 May 2021
... methylation, facilitate pairing of homologous chromosomes during the meiotic prophase of mammalian spermatogenesis. In pro-spermatogonia, de novo DNA methylation plays a key role in completing meiotic prophase and initiating meiotic division. However, the role of maintenance DNA methylation in the regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev185629.
Published: 17 March 2020
... with significant epigenetic changes. Notably, we identify a cohort of differentially methylated regions (DMRs), most of which gain DNA methylation between the early and late stages of decidualisation. These DMRs are enriched at progesterone-responsive gene loci that are essential for reproductive function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev174722.
Published: 12 September 2019
... regulators in development and disease, and has shown that disruption of DNMTs increases cell-cell variability. DNA methylation DNA methyltransferases Pluripotency Single-cell RNA-sequencing Isogenic populations of cells can exhibit substantial phenotypic variation, which can, in turn, play...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev170217.
Published: 27 June 2019
... sequence for a fluorescent protein (tdTomato). DNA methylation spreads from the endogenous locus into the reporter, leading to its silencing. (D) The direct readout of DNA or histone methylation at a locus of interest is possible upon reconstitution of a split fluorescent protein (Venus), the constituents...
Journal Articles
Journal: Development
Development (2019) 146 (7): dev171017.
Published: 11 April 2019
... miRNA-gene regulatory circuit, conserved in cancer, that controls the timing of neural crest epithelial-to-mesenchymal transition. EMT Neural crest miR-203 Snail2 DNA methylation Phf12 Migration The neural crest is a transient embryonic cell population that arises...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev170902.
Published: 15 March 2019
... sequence-based inheritance in mammals remains rudimentary at best. The higher-order level of information that is encoded by 3D chromatin structure, which is established via multiple hereditary information carriers such as DNA methylation, histone modifications and RNAs under their distinctive...
Journal Articles
Journal: Development
Development (2018) 145 (7): dev160622.
Published: 29 March 2018
...Jennifer M. SanMiguel; Lara K. Abramowitz; Marisa S. Bartolomei ABSTRACT Imprinted genes are expressed from one parental allele and regulated by differential DNA methylation at imprinting control regions (ICRs). ICRs are reprogrammed in the germline through erasure and re-establishment of DNA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev157412.
Published: 8 January 2018
... by epigenetic regulators. Among these, ubiquitin-like with PHD and RING finger domains 1 (Uhrf1) is reported to have diverse epigenetic functions, including regulation of DNA methylation. However, the physiological functions of Uhrf1 in skeletal tissues remain unclear. Here, we show that limb mesenchymal cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2925–2939.
Published: 15 August 2017
... , A. , Roberts , K. , Edberg , J. , Chatham , W. W. and Kimberly , R. P. ( 2013 ). Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations . PLoS Genet.   9 , e1003678...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2016) 143 (23): 4452–4461.
Published: 1 December 2016
...Yuhua Wang; Xueyi Xue; Jian-Kang Zhu; Juan Dong DNA methylation and histone modifications interact to modulate gene expression in biological organisms. The histone demethylase IBM1 suppresses DNA methylation and gene silencing, primarily by targeting genic regions in the Arabidopsis genome...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4161–4166.
Published: 15 November 2016
... that this ‘imprinting reporter mouse’ can be used to detect tissue-specific Dlk1 expression patterns in developing embryos. We also apply this system to pluripotent cell culture and demonstrate that it faithfully indicates DNA methylation changes induced upon cellular reprogramming. Finally, the reporter system reveals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (22): 3833–3844.
Published: 15 November 2015
...Hitomi Matsuzaki; Eiichi Okamura; Takuya Takahashi; Aki Ushiki; Toshinobu Nakamura; Toru Nakano; Kenichiro Hata; Akiyoshi Fukamizu; Keiji Tanimoto Genomic imprinting is a major monoallelic gene expression regulatory mechanism in mammals, and depends on gamete-specific DNA methylation of specialized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2163–2172.
Published: 15 June 2015
...Ellen N. Elliott; Karyn L. Sheaffer; Jonathan Schug; Thaddeus S. Stappenbeck; Klaus H. Kaestner The DNA methyltransferase Dnmt1 maintains DNA methylation patterns and genomic stability in several in vitro cell systems. Ablation of Dnmt1 in mouse embryos causes death at the post-gastrulation stage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 510–521.
Published: 1 February 2015
...Vinitha Jacob; Yelena Chernyavskaya; Xintong Chen; Poh Seng Tan; Brandon Kent; Yujin Hoshida; Kirsten C. Sadler UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to hemimethylated DNA during replication and is essential for maintaining DNA methylation. uhrf1 mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (13): 2702–2711.
Published: 1 July 2014
...Robert A. Drewell; Eliot C. Bush; Emily J. Remnant; Garrett T. Wong; Suzannah M. Beeler; Jessica L. Stringham; Julianne Lim; Benjamin P. Oldroyd In honey bees ( Apis mellifera ), the epigenetic mark of DNA methylation is central to the developmental regulation of caste differentiation, but may also...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (13): 2568–2580.
Published: 1 July 2014
...Ryohei Nakamura; Tatsuya Tsukahara; Wei Qu; Kazuki Ichikawa; Takayoshi Otsuka; Katsumi Ogoshi; Taro L. Saito; Kouji Matsushima; Sumio Sugano; Shinichi Hashimoto; Yutaka Suzuki; Shinichi Morishita; Hiroyuki Takeda DNA methylation is a fundamental epigenetic modification in vertebrate genomes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 2024–2034.
Published: 15 May 2014
...: Department of Biology, University of Alabama at Birmingham, AL 35294, USA. ¶ Author for correspondence ( stor@uchicago.edu ) Ssm1 KRAB-zinc finger genes DNA methylation Gene inactivation ES cells Mouse development The role of epigenetic modification in the control of gene expression...
Includes: Supplementary data