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Keywords: DNA damage response
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Journal Articles

DNA damage signals from somatic uterine tissue arrest oogenesis through activated DAF-16

Gautam Chandra Sarkar, Umanshi Rautela, Anita Goyala, Sudeshna Datta, Nikhita Anand, Anupama Singh, Prachi Singh, Manish Chamoli, Arnab Mukhopadhyay
Journal: Development
Development (2023) 150 (17): dev201472.
https://doi.org/10.1242/dev.201472
Published: 12 September 2023
...Gautam Chandra Sarkar; Umanshi Rautela; Anita Goyala; Sudeshna Datta; Nikhita Anand; Anupama Singh; Prachi Singh; Manish Chamoli; Arnab Mukhopadhyay ABSTRACT Germ line integrity is crucial for progeny fitness. Organisms deploy the DNA damage response (DDR) signaling to protect the germ line from...
View articletitled, DNA damage signals from somatic uterine tissue arrest oogenesis through activated DAF-16
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Includes: Supplementary data
Journal Articles

DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes

Simon I. R. Lane, Stephanie L. Morgan, Tianyu Wu, Josie K. Collins, Julie A. Merriman, Elias ElInati, James M. Turner, Keith T. Jones
Journal: Development
Development (2017) 144 (19): 3475–3486.
https://doi.org/10.1242/dev.153965
Published: 1 October 2017
... oocyte-specific knockouts we find the response does not require the DNA damage response kinases ATM or ATR. Furthermore, checkpoint activation does not occur in response to DNA damage in fully mature eggs during meiosis II, despite the divisions being separated by just a few hours. Therefore, mouse...
View articletitled, DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes
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Includes: Supplementary data
Journal Articles

Differential DNA damage signalling and apoptotic threshold correlate with mouse epiblast-specific hypersensitivity to radiation

Audrey Laurent, Francesco Blasi
Journal: Development
Development (2015) 142 (21): 3675–3685.
https://doi.org/10.1242/dev.125708
Published: 1 November 2015
... of 53BP1 to DNA breaks and induction of p53 in the epiblast only. Epiblast Apoptosis DNA damage response Trp53bp1 Cytoplasmic apoptotic priming Maintenance of genomic integrity is important in stem cells for tissue differentiation and homeostasis ( Blanpain et al., 2011...
View articletitled, Differential DNA damage signalling and apoptotic threshold correlate with mouse epiblast-specific hypersensitivity to radiation
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Includes: Supplementary data
Journal Articles

Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium

Ellen N. Elliott, Karyn L. Sheaffer, Jonathan Schug, Thaddeus S. Stappenbeck, Klaus H. Kaestner
Journal: Development
Development (2015) 142 (12): 2163–2172.
https://doi.org/10.1242/dev.117341
Published: 15 June 2015
... maintenance DNA methylation, the rapidly growing epithelium displays increased double-strand breakage, activation of the DNA damage response, and loss of progenitor cells due to both premature differentiation and apoptosis. We validate these results utilizing in vitro organoid cultures, demonstrating...
View articletitled, Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium
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Includes: Supplementary data