... networks, which include the distal-less (Dlx) gene family. However, the functional significance of Dlx5 in patterning the oropharyngeal region has remained unknown. Here, we show that loss of Dlx5 leads to a shortened soft palate and an absence of the levator veli palatini, palatopharyngeus...

... Osx1 Sp7 Dlx5 Grhl3 Mouse MLB13 cells National Institute of Arthritis and Musculoskeletal and Skin Diseases 10.13039/100000069 R01 AR055904 Bone morphogenetic proteins (BMPs) and canonical Wnts (cWnts) play essential roles in the skeleton. BMPs, originally identified...

.... Here, we show that ectethmoid formation depends upon Dlx5 and Dlx6 expression in a restricted ectodermal territory of the anterior neural folds, which we name NF-ZA. In both chick and mouse neurulas, Dlx5 and Dlx6 expression is mostly restricted to NF-ZA. Simultaneous Dlx5 and Dlx6 inactivation...

... the onset of fusion, but how the O-N pattern is established and how it relates to the expansion and fusion of the palatal shelves are unknown. Here we address these questions and show that O-N patterning is associated with the expansion and fusion of the palatal shelves and that Dlx5 is required for the O-N...

... neural crest (CNC) cell proliferation Differentiation Frontal bone development DLX5 FGFR TGFβ Twist1 Mouse Skull vault malformations are a major group of congenital birth defects in humans. The cranial neural crest (CNC), a population of multipotent embryonic progenitor...

..., IN 46285, USA 23 9 2005 ©2005. 2005 FGF Vomeronasal organ Neurogenesis Olfactory epithelium Nasal cavity Stem cell Apoptosis Cre recombinase Fgf8 Foxg1 Sox2 Pax6 Mash1 Neurogenin 1 Ncam1 Pyst1 Shh Dlx5 Neuronal progenitor Mouse mutant...

.... Int. J. Dev. Biol. 45 , 681 -684. Luo, T., Matsuo-Takasaki, M. and Sargent, T. (2001b). Distinct roles for Distal-less genes Dlx3 and Dlx5 in regulating ectodermal development in Xenopus. Mol. Reprod. Dev. 60 , 331 -337. Luo, T., Matsuo-Takasaki, M., Thomas, M. L., Weeks, D. L...

... 2002. 2002 Emx1 Dlx2 En1 Dlx5 Neurosphere Mouse Cell fate The vertebrate brain is divided into specialized regions during development. A prevailing model proposes that regional specialization in the vertebrate brain is broadly established through the formation of transient...

...Dario Acampora; Giorgio R. Merlo; Laura Paleari; Barbara Zerega; Maria Pia Postiglione; Stefano Mantero; Eva Bober; Ottavia Barbieri; Antonio Simeone; Giovanni Levi The Dlx5 gene encodes a Distal-less -related DNA-binding homeobox protein first expressed during early embryonic development...

...Michael J. Depew; Jen Kuei Liu; Jason E. Long; Robert Presley; Juanito J. Meneses; Roger A. Pedersen; John L. R. Rubenstein We report the generation and analysis of mice homozygous for a targeted deletion of the Dlx5 homeobox gene. Dlx5 mutant mice have multiple defects in craniofacial structures...

... to the periphery. The prospective epidermis at early stages is characterized by the expression of the homeobox gene DLX5 , which remains an epidermal marker during gastrulation and neurulation. Later, some DLX5 -expressing cells become internalized into the ventral forebrain and the neural crest at the hindbrain...