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Development (2008) 135 (7): 1347–1353.
Published: 1 April 2008
...Tsuyoshi Araki; Judith Langenick; Marianne Gamper; Richard A. Firtel; Jeffrey G. Williams STATc becomes tyrosine phosphorylated and accumulates in the nucleus when Dictyostelium cells are exposed to the prestalk cell inducer Differentiation inducing factor 1 (DIF-1), or are subjected to hyper...
Development (2006) 133 (9): 1715–1724.
Published: 1 May 2006
...Masashi Fukuzawa; Natasha V. Zhukovskaya; Yoko Yamada; Tsuyoshi Araki; Jeffrey G. Williams PstA and pstO cells are the two major populations in the prestalk region of the Dictyostelium slug and DIF-1 is a low molecular weight signalling molecule that selectively induces pstO cell-specific gene...
Eryong Huang, Simone L. Blagg, Thomas Keller, Mariko Katoh, Gad Shaulsky, Christopher R. L. Thompson
Development (2006) 133 (3): 449–458.
Published: 1 February 2006
...Eryong Huang; Simone L. Blagg; Thomas Keller; Mariko Katoh; Gad Shaulsky; Christopher R. L. Thompson The signalling molecule DIF-1 is required for normal cell fate choice and patterning in Dictyostelium . To understand how these developmental processes are regulated will require knowledge of how...
Development (2006) 133 (3): 439–448.
Published: 1 February 2006
...Natasha V. Zhukovskaya; Masashi Fukuzawa; Yoko Yamada; Tsuyoshi Araki; Jeffrey G. Williams The ecmA gene is specifically expressed in prestalk cells and its transcription is induced by the chlorinated hexaphenone DIF-1. We have purified a novel bZIP transcription factor, DimB, by affinity...
Development (2004) 131 (18): 4555–4565.
Published: 15 September 2004
...-inducing action of DIF-1 but largely refractory to the repressive effect exerted by extracellular cAMP. During normal development, apically situated prestalk cells express the ecmB gene just as they commit themselves to stalk cell differentiation. In the Ax2/gskA– mutant, ecmB is expressed throughout...
Development (2004) 131 (3): 513–523.
Published: 1 February 2004
...Christopher R. L. Thompson; Qing Fu; Caroline Buhay; Robert R. Kay; Gad Shaulsky The intermingled differentiation and sorting out of Dictyostelium prestalk-O and prespore cells requires the diffusible signaling molecule DIF-1, and provides an example of a spatial information-independent patterning...
Development (2001) 128 (24): 4959–4966.
Published: 15 December 2001
...Robert R. Kay; Christopher R. L. Thompson To investigate how cell type proportions are regulated during Dictyostelium development, we have attempted to find out which cell type produces DIF-1, a diffusible signal molecule inducing the differentiation of prestalk-O cells. DIF-1 is a chlorinated...
Development (1991) 113 (Supplement_1): 131–139.
Published: 1 January 1991
... by signalling between the cells. A number of diffusible signal molecules have been discovered, including cyclic AMP, the chemoattractant in aggregation, and DIF-1, a novel chlorinated phenyl alkanone, which acts as a specific inducer of stalk cell differentiation. The migrating slug contains three types...
Development (1989) 107 (Supplement): 81–90.
Published: 1 April 1989
... those discovered to date are low MW diffusible compounds: cAMP, adenosine, NH3 and DIFs 1–3. The DIFs are assayed by their ability to induce isolated amoebae to differentiate into stalk cells and have been identified as a family of chlorinated phenyl alkanones. The diversification of amoebae...