...Enrique Martín-Blanco; Fernando Roch; Elizabeth Noll; Antonio Baonza; Joseph B. Duffy; Norbert Perrimon The Drosophila EGF receptor (DER) is required for the specification of diverse cell fates throughout development. We have examined how the activation of DER controls the development of vein...

..., the receptor tyrosine kinase DER represses expression of proneural genes, achaete and scute , and is required for the formation of neuroblasts. Most of the early function of DER is likely to be mediated by the Ras-MAP kinase signaling pathway, which is activated in the intermediate column, since a loss...

... transcription factor that is negatively regulated by the Ras1-MAP kinase signaling cascade. We find that Anterior Open must be inactivated for posterior Engrailed cells to adopt their correct fate. This is achieved by the EGF receptor (DER), which is required autonomously in the Engrailed cells to trigger...

... of homozygous mutant cells in a heterozygous background. Mutations in each of these signalling components produce a very similar set of phenotypes. These phenotypes resemble those caused by loss-of-function mutations in the Drosophila EGF receptor homolog (DER). It appears that these components form...

...K. L. Kammermeyer; Samuel C. Wadsworth ABSTRACT Expression of the Drosophila homologue (DER) of the human epidermal growth factor (EGF) receptor has been studied during development by RNA blot hybridizations and in situ hybridizations. One of the hypothetical functions of the protein encoded...