... not persist in embryos lacking NvSoxB(2). Previous studies in Nematostella reported an increase in the expression of marker genes for sensory and ganglion cells after treatment with DAPT [a chemical inhibitor of γ-secretase ( Micchelli et al., 2003 )], and tied this effect to an inhibition...

...,N-P,R,S,U,W-Y,A'-C', 50 μm. Analysis of myosin VIIa expression in DAPT-treated cultures confirmed that Notch inactivation resulted in a dose-dependent increase in myosin VIIa expression in wild-type and COUP-TFI -/- cochleae( Fig. 5A ). Again, statistical significance was reached at 2.5...

... mouse metanephroi in the presence of a γ-secretase inhibitor, N - S -phenyl-glycine- t -butyl ester (DAPT), to block Notch signaling. We observed slightly reduced ureteric bud branching but normal mesenchymal condensation and expression of markers indicating that mesenchyme induction had occurred...