...Hao Chen; Katherine E. Williams; Elaine Y. Kwan; Mirhan Kapidzic; Kenisha A. Puckett; Rayyan K. Aburajab; Joshua F. Robinson; Susan J. Fisher ABSTRACT During human pregnancy, cytotrophoblasts (CTBs) from the placenta differentiate into specialized subpopulations that play crucial roles in proper...

.../fetus and the mother. We isolated EVs from second trimester human cytotrophoblasts (CTBs) by differential ultracentrifugation and characterized them using transmission electron microscopy, immunoblotting and mass spectrometry. The 100,000 g pellet was enriched for vesicles with a cup-like morphology...

... of proliferative cytotrophoblast, where it is co-expressed with the transcription factor TEAD4. As TEAD4 is involved in trophectoderm specification in the mouse, we posit a regulatory role for VGLL1 in early events during human placental development. * Authors for correspondence ([email protected] ; mparast...

...Tamara Garrido-Gomez; Katherine Ona; Mirhan Kapidzic; Matthew Gormley; Carlos Simón; Olga Genbacev; Susan J. Fisher Pre-eclampsia (PE), which affects ∼8% of first pregnancies, is associated with faulty placentation. Extravillous cytotrophoblasts (CTBs) fail to differentiate properly, contributing...

...Kristy Red-Horse; Mirhan Kapidzic; Yan Zhou; Kui-Tzu Feng; Harbindar Singh; Susan J. Fisher In humans, fetal cytotrophoblasts leave the placenta and enter the uterine wall, where they preferentially remodel arterioles. The fundamental mechanisms that govern these processes are largely unknown...

...Mary J. Janatpour; Michael T. McMaster; Olga Genbacev; Yan Zhou; Jian-Yun Dong; James C. Cross; Mark A. Israel; Susan J. Fisher* ABSTRACT During early human placental development, the conceptus attaches itself to the uterus through cytotrophoblast invasion. Invasive cytotrophoblast cells...