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Keywords: Cyclopamine
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Journal Articles
Journal: Development
Development (2017) 144 (7): 1165–1176.
Published: 1 April 2017
... hedgehog Osteoblasts Calcification Basal epidermis Basement membrane Smoothened inhibitor Cyclopamine BMS-833923 Unlike mammalian appendages, the adult zebrafish caudal fin perfectly restores tissue organization, size and shape in response to injury or resection ( Tornini and Poss, 2014...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (8): 1361–1371.
Published: 15 April 2010
... and Whitfield, 2009 ). ptc1 –/– ; lep –/– double-mutant embryos were sorted from siblings at 13-14S based on somite phenotype ( Koudijs et al., 2008 ). Ten to 15 embryos were treated in each well of a 12-well culture dish in 2 ml of embryo medium containing 0.25-50 μM cyclopamine/1% ethanol...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3789–3799.
Published: 15 November 2008
... of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 16 , 2743 -2748. Chen, J. N., Haffter, P., Odenthal, J., Vogelsang, E., Brand,M., van Eeden, F. J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M.,Heisenberg, C. P. et al. ( 1996 ). Mutations affecting...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (16): 3643–3656.
Published: 15 August 2005
... † Present address: Biology Department, Williams College, Williamstown, MA 01267, USA 3 6 2005 ©2005. 2005 Zebrafish Cyclopamine Morpholino Axon guidance POC Chiasm Gfap Glia hedgehog slit you-too In bilateral organisms, some axons cross the midline of the CNS...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (14): 3243–3253.
Published: 15 July 2005
... the spinal cord but is also transmitted to the surrounding blastema. Cyclopamine treatment revealed that hedgehog signaling is not only required for DV patterning of the regenerating spinal cord but also had profound effects on the regeneration of surrounding, mesodermal tissues. Proliferation of tail...
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (22): 5351–5362.
Published: 15 November 2003
... of neurogenin1 ( ngn1 ), a gene required for determination of DRG precursors. Cell transplantation experiments demonstrate that Hh acts directly on DRG neuron precursors. Blocking Hh pathway activation at later stages of embryogenesis with the steroidal alkaloid, cyclopamine,further reveals that the requirement...
Journal Articles
Journal: Development
Development (2003) 130 (8): 1549–1564.
Published: 15 April 2003
... gli1 expression present in smu/smo mutant embryos is due to Hh signaling that results from maternal Smoothened function, we treated embryos with the alkaloid cyclopamine from the 2-cell stage throughout embryogenesis. Cyclopamine is thought to completely block Hh signaling at the level of Smoothened...
Journal Articles
Journal: Development
Development (2003) 130 (1): 15–28.
Published: 1 January 2003
... Cerebellum Sonic hedgehog Proliferation Cyclopamine Medulloblastoma Nmyc Neural precursor TRRAP Mouse Signaling by the hedgehog family of secreted glycoproteins has been highly conserved through evolution ( Ingham and McMahon, 2001 ). Hedgehog activity is required for fundamental processes...
Journal Articles
Journal Articles
Journal: Development
Development (1998) 125 (18): 3553–3562.
Published: 15 September 1998
...John P. Incardona; William Gaffield; Raj P. Kapur; Henk Roelink ABSTRACT The steroidal alkaloid cyclopamine produces cyclopia and holoprosencephaly when administered to gastrulation-stage amniote embryos. Cyclopamine-induced malformations in chick embryos are associated with interruption of Sonic...