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Keywords: Cyclin-dependent kinase inhibitor
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Journal Articles
Georges Mairet-Coello, Anna Tury, Elise Van Buskirk, Kelsey Robinson, Matthieu Genestine, Emanuel DiCicco-Bloom
Journal:
Development
Development (2012) 139 (3): 475–487.
Published: 1 February 2012
.... Here, we defined the roles of cyclin-dependent kinase inhibitor (CKI) p57 KIP2 , an important regulator of G1 phase, using deletion mutant mice. Mutant mice displayed macroencephaly associated with cortical hyperplasia during late embryogenesis and postnatal development. Embryonically, proliferation...
Includes: Supplementary data
Journal Articles
bHLH transcription factor Her5 links patterning to regional inhibition of neurogenesis at the midbrain-hindbrain boundary
Available to PurchaseAndrea Geling, Motoyuki Itoh, Alexandra Tallafuß, Prisca Chapouton, Birgit Tannhäuser, John Y. Kuwada, Ajay B. Chitnis, Laure Bally-Cuif
Journal:
Development
Development (2003) 130 (8): 1591–1604.
Published: 15 April 2003
... panel), and is necessary for the increased level of proliferation of territory A (F, right panel). (G-J) Expression of the cyclin-dependent kinase inhibitor-encoding gene p27 Xic1 -a is downregulated by Her5 within the IZ. Expression of p27 Xic1 -a and pax2.1 , as indicated (bottom left,color-coded...
Journal Articles
Genetic rescue of cell number in a mouse model of microphthalmia:interactions between Chx10 and G1-phase cell cycle regulators
Available to Purchase
Journal:
Development
Development (2003) 130 (3): 539–552.
Published: 1 February 2003
...-mail: [email protected]) 31 10 2002 © 2003. 2003 Proliferation Cell cycle Cyclin-dependent kinase inhibitor Ocular retardation Microphthalmia Homeobox Retina Chx10 p27 Kip1 Cyclin D1 The proliferative expansion of the neuroepithelium is a crucial process...
Journal Articles
p27 Kip1 links cell proliferation to morphogenesis in the developing organ of Corti
Available to Purchase
Journal:
Development
Development (1999) 126 (8): 1581–1590.
Published: 15 April 1999
...-proliferative state throughout the adult life of the animal. Here we report that the correct timing of cell cycle withdrawal in the developing organ of Corti requires p27 Kip1 , a cyclin-dependent kinase inhibitor that functions as an inhibitor of cell cycle progression. p27 Kip1 expression is induced...