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Keywords: Cyclin D1
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Journal Articles
Journal: Development
Development (2012) 139 (23): 4395–4404.
Published: 01 December 2012
... demonstrate that the induced proliferation of Sox2-positive cells may be mediated by the cell cycle regulator cyclin D1. Lastly, we provide evidence that the mitotic Sox2-positive cells are competent to differentiate into hair cells. Combined, our data suggest that Wnt/β-catenin signaling has a dual function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1771–1782.
Published: 01 May 2011
... and differentiation is indispensable. It remains unknown whether proliferation and differentiation are related in these embryonic cardiomyocytes. We focused on abnormal phenotypes, such as hyperproliferation, inhibition of differentiation and enhanced expression of cyclin D1 in cardiomyocytes of mice with mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (5): 799–803.
Published: 01 March 2008
...-to-S phase transition of the eye cells, and results in severely reduced eyes. This role in cell cycle control is mediated by meis1 regulating cyclin D1 and c-myc transcription. The forced maintenance of meis1 expression in cell clones is incompatible with the normal differentiation of the meis1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (5): 805–811.
Published: 01 March 2008
... that progenitor cells expressing Meis1 together with Meis2 proliferate more rapidly than cells expressing Meis1 alone. Transfection of Meis-inactivating constructs reduced the expression of cyclin D1 ( Ccnd1 ) in the eye primordium and co-transfection of cyclin D1 partially rescued RPC proliferation. Collectively...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (19): 3929–3937.
Published: 01 October 2006
... to their mature location in the inner granule layer. In this study, we examined the expression of D type cyclins in GNPs during cerebellar development and showed that GNPs in early development expressed only cyclin D1, whereas later GNPs expressed both cyclins D1 and D2. Coinciding with the period of cyclin D1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (6): 1045–1057.
Published: 15 March 2006
... stimulate guard hair placode formation, suggesting a crucial role for NF-κB in placode development. In downless and c IκBαΔN mice, placodes start to develop,but rapidly abort in the absence of EdaR/NF-κB signalling. We show that NF-κB activation is essential for induction of Shh and cyclin D1 expression...
Journal Articles
Journal: Development
Development (2004) 131 (21): 5327–5339.
Published: 01 November 2004
..., BMP regulates NC delamination in a cell cycle-dependent manner. We then examined the hypothesis that Wnt signaling, which controls G1/S transition by regulating cyclin D1 transcription( Tetsu and McCormick, 1999 )mediates BMP activity on both G1/S transition and NC delamination. We find...
Journal Articles
Journal: Development
Development (2004) 131 (14): 3469–3479.
Published: 15 July 2004
... in mid-pregnancy and inappropriately express β-casein, cyclin D1 andβ-catenin protein. Increased ductal growth was also observed in the glands of ovariectomized female mice, as well as of transgenic male mice. MTA1 dysregulation in mammary epithelium and cancer cells triggered downregulation...
Journal Articles
Journal: Development
Development (2003) 130 (3): 539–552.
Published: 01 February 2003
... Kip1 . We find that p27 Kip1 is abnormally present in progenitors of Chx10 -null retinas, and that its ectopic localization is responsible for a significant amount of the proliferation defect in this microphthalmia model system. mRNA and protein expression patterns in these mice and in cyclin D1-null...
Journal Articles
Journal: Development
Development (2001) 128 (24): 5099–5108.
Published: 15 December 2001
... or a constitutively active Smo allele ( Smo *) specifically in the cartilage using the bigenic UAS-Gal4 system, we demonstrate that activation of the Ihh signaling pathway is sufficient to promote chondrocyte proliferation. Finally, expression of cyclin D1 is markedly downregulated when either Ihh or Smo activity...