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Keywords: Cyclin D1
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Journal Articles
Journal: Development
Development (2012) 139 (23): 4395–4404.
Published: 1 December 2012
... demonstrate that the induced proliferation of Sox2-positive cells may be mediated by the cell cycle regulator cyclin D1. Lastly, we provide evidence that the mitotic Sox2-positive cells are competent to differentiate into hair cells. Combined, our data suggest that Wnt/β-catenin signaling has a dual function...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2008) 135 (5): 805–811.
Published: 1 March 2008
... that progenitor cells expressing Meis1 together with Meis2 proliferate more rapidly than cells expressing Meis1 alone. Transfection of Meis-inactivating constructs reduced the expression of cyclin D1 ( Ccnd1 ) in the eye primordium and co-transfection of cyclin D1 partially rescued RPC proliferation. Collectively...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (19): 3929–3937.
Published: 1 October 2006
... to their mature location in the inner granule layer. In this study, we examined the expression of D type cyclins in GNPs during cerebellar development and showed that GNPs in early development expressed only cyclin D1, whereas later GNPs expressed both cyclins D1 and D2. Coinciding with the period of cyclin D1...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (21): 5327–5339.
Published: 1 November 2004
... their transcription. Unilateral electroporation of Xdd1, dNLEF1 orβ-catenin-engrailed completely abolished expression of Cad6B, Pax3 and Msx1 along the electroporated region( Fig. 6B-E and not shown),whereas control GFP had no effect ( Fig. 6A and not shown). Expression of cyclin D1 , a direct target...
Journal Articles
Journal: Development
Development (2004) 131 (14): 3469–3479.
Published: 15 July 2004
... in mid-pregnancy and inappropriately express β-casein, cyclin D1 andβ-catenin protein. Increased ductal growth was also observed in the glands of ovariectomized female mice, as well as of transgenic male mice. MTA1 dysregulation in mammary epithelium and cancer cells triggered downregulation...
Journal Articles
Journal: Development
Development (2003) 130 (3): 539–552.
Published: 1 February 2003
... Kip1 . We find that p27 Kip1 is abnormally present in progenitors of Chx10 -null retinas, and that its ectopic localization is responsible for a significant amount of the proliferation defect in this microphthalmia model system. mRNA and protein expression patterns in these mice and in cyclin D1-null...
Journal Articles
Journal: Development
Development (2001) 128 (24): 5099–5108.
Published: 15 December 2001
... or a constitutively active Smo allele ( Smo *) specifically in the cartilage using the bigenic UAS-Gal4 system, we demonstrate that activation of the Ihh signaling pathway is sufficient to promote chondrocyte proliferation. Finally, expression of cyclin D1 is markedly downregulated when either Ihh or Smo activity...