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Keywords: Cyclin
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Journal Articles
Journal Articles
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Plant development
Journal: Development
Development (2018) 145 (6): dev160671.
Published: 21 March 2018
... that the D-type cyclin, CYCD7;1, is specifically expressed just prior to the symmetric guard cell-forming division, and that it is limiting for this division. Further, we find that CYCD7;1 is capable of promoting divisions in multiple contexts, likely through RBR1-dependent promotion of the G1/S transition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (15): 3079–3093.
Published: 1 August 2013
...Shuhui Lim; Philipp Kaldis Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Close cooperation between this trio is necessary for ensuring orderly progression through the cell cycle...
Journal Articles
Journal: Development
Development (2009) 136 (10): 1687–1696.
Published: 15 May 2009
... by M phase when MAPK remains active, owing to poly(A)-independent repression of cyclin A and B synthesis. By contrast, inactivation of MAPK alone induces M phase, even when S phase is inhibited by constitutively active Rsk. Thus, there is a divergence of separate pathways downstream of MAPK...
Journal Articles
Journal: Development
Development (2008) 135 (20): 3389–3400.
Published: 15 October 2008
...Ande Satyanarayana; Cyril Berthet; Javier Lopez-Molina; Vincenzo Coppola; Lino Tessarollo; Philipp Kaldis It was believed that Cdk2-cyclin E complexes are essential to drive cells through the G1-S phase transition. However, it was discovered recently that the mitotic kinase Cdk1 (Cdc2a) compensates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (6): 1101–1110.
Published: 15 March 2007
... to complete cytokinesis, resulting in multinucleate cells with gapped walls and cell wall stubs in diverse tissues. These defects correlate with the selective reduction of transcript levels of several G2/M phase-specific genes, which include B2-type cyclin ( CYCB2 ), CDC20.1 and KNOLLE ( KN ). These genes...
Journal Articles
Journal: Development
Development (2006) 133 (20): 3983–3992.
Published: 15 October 2006
.... Finally, Sema3d overexpression rescues reduced proliferation caused byΔTCF expression, suggesting that Sema3d lies downstream of Wnt/TCF signaling in the molecular pathway thought to control cell cycle in NCC precursors. © 2006. 2006 Neural crest Zebrafish Semaphorin TCF Cell cycle Cyclin...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (7): 1543–1552.
Published: 1 April 2004
... of oogenesis). Stage IV oocytes contain a store of inactive pre-MPF (Tyr15-phosphorylated Cdc2 bound to cyclin B2); the Cdc25 phosphatase that catalyzes Tyr15 dephosphorylation of Cdc2 is also present. However, the positive feedback loop that allows MPF autoamplification is not functional at this stage...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4349–4359.
Published: 1 November 2001
...Mike Boxem; Sander van den Heuvel We have investigated the regulation of cell-cycle entry in C. elegans , taking advantage of its largely invariant and completely described pattern of somatic cell divisions. In a genetic screen, we identified mutations in cyd-1 cyclin D and cdk-4 Cdk4/6. Recent...
Journal Articles
Journal: Development
Development (2000) 127 (3): 549–558.
Published: 1 February 2000
... of these correlations, we used an adenovirus vector to maintain Id-2 protein expression in cultured cytotrophoblasts. Compared to control ( lacZ -expressing) cells, cytotrophoblasts transduced to constitutively express Id-2 retained characteristics of undifferentiated cells: α1 integrin expression was low and cyclin B...
Journal Articles
Journal: Development
Development (1998) 125 (24): 4989–4997.
Published: 15 December 1998
... shortly after GVBD with a slightly higher level in CBA/Kw oocytes, which may correspond to the presence of a larger pool of cyclin B1 in prophase CBA/Kw oocytes. After GVBD, the rate of cyclin B1 synthesis is higher in CBA/Kw than in KE oocytes, whilst the overall level of protein synthesis and the amount...
Journal Articles
Journal: Development
Development (1993) 119 (3): 673–690.
Published: 1 November 1993
...Helena E. Richardson; Louise V. O’Keefe; Steven I. Reed; Robert Saint ABSTRACT We have isolated a Drosophila homolog of the human G 1 -specific cyclin E gene. Cyclin E proteins thus constitute an evolutionarily conserved subfamily of metazoan cyclins. The Drosophila cyclin E gene, DmcycE , encodes...
Journal Articles
Journal: Development
Development (1991) 111 (4): 1173–1178.
Published: 1 April 1991
...D. L. Weeks; J. A. Walder; John M. Dagle ABSTRACT The control of the cell cycle is dependent on the ability to synthesize and degrade proteins called cyclins. When antisense oligonucleotides are used to deplete Xenopus embryos of mRNA encoding cyclin B protein, embryonic cleavage is inhibited...
Journal Articles
Journal: Development
Development (1990) 109 (1): 149–156.
Published: 1 May 1990
...-phase-specific histone Hl kinase activity when it interacts with cyclins, which are proteins that oscillate through the cell cycle and are thought to regulate p34 cdc2 activity. Cyclins can induce M phase when introduced into fully grown Xenopus oocytes and cyclin may play a role in normal oocyte...
Journal Articles
Journal: Development
Development (1990) 108 (4): 525–542.
Published: 1 April 1990
... by transient increases in intracellular free calcium. The Ca i transients control cell cycle progression by translational and post-translational regulation of the cell cycle control proteins pp34 and cyclin. The START Ca i transient leads to phosphorylation of pp34 and cyclin synthesis. The mitosis ENTRY Ca i...