... is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken...

... the integrity of cyclic gene expression domains in these embryos. At the 10-somite stage, embryos with reduced her1 and her7 function display a fully penetrant salt and pepper class cyclic domain defect (her1 25/25, her7 23/23, dlc 28/28 embryos, Fig. 9 O,P,U, respectively). A similar phenotype...