...Caleb A. Doll; Kendal Broadie The activity-dependent refinement of neural circuit connectivity during critical periods of brain development is essential for optimized behavioral performance. We hypothesize that this mechanism is defective in fragile X syndrome (FXS), the leading heritable cause...

... days after adult eclosion, glial division was scarcely observed in the intact brain. Moreover, 8 days after adult eclosion, glial cells no longer responded to brain injury. These results suggest that the life of an adult fly can be divided into two phases: the first week, as a critical period...

... in part from dendrite growth in response to afferent input during a sensitive period in early postnatal life. 01 08 1993 © 1994 by Company of Biologists 1994 activity-dependent development spinal cord critical period motor neuron dendrite Adult mammalian motor neurons receive...

... on E15, followed by recovery 2 days later so that animals were motile during the period of change in expression of MHC isoforms, was as effective as full paralysis. These experiments define a critical period (E15–17) during which foetuses must be active if slow muscle fibres are to differentiate during...

...C. K. Govind; Joanne Pearce ABSTRACT Lateralization of the paired claws into a major crusher and a minor cutter type is determined during the 4th and 5th stages of juvenile development of the lobster, Homarus americanus . Loss of both claws during this critical period delays the determination...

... and unrestricted feeding from E21 onwards allowed a normal number of fibres to develop from this time on, although the initial deficit was never restored. These experiments define a critical period in muscle development during which the potential maximum number of secondary myotubes is determined. * To whom...