... precursors of the craniofacial skeleton that have begun to migrate toward the pharyngeal arches in three streams. In IrxAb −/− ; irx7 −/− mutants, dlx2a expression, particularly in the first (mandibular) stream, was reduced ( Fig. 4 B). A similar and preferential loss of mandibular CNCCs in IrxAb...

... and involvement of alx3 in skeletal cell morphology and differentiation timing affecting neurocranium shape. Zebrafish Craniofacial skeleton Neurocranium scRNA-seq Differentiation Neural crest cells Cartilage Bone Alx The vertebrate head skeleton has many cartilaginous and bony elements...

... hypothetical mechanism accounting for mutant phenotypic variation is progenitor cells variably choosing between two alternative fates during development. Zebrafish mef2ca b1086 mutants develop tremendously variable ectopic bone in their hyoid craniofacial skeleton. Here, we report evidence that a key component...

... development. Targeted gene knockdown using the morpholino antisense oligonucleotide technique indicated a vital role of the provitamin A-converting enzyme. Morpholino-injected embryos developed a morphological phenotype that included severe malformation of the eyes, the craniofacial skeleton and pectoral fins...

...-mail: [email protected] ) 24 10 2001 © 2002. 2002 Sox9 Neural crest Craniofacial skeleton Morpholino antisense Xenopus The neural crest is a unique embryonic structure composed of a migratory population of multipotent cells arising at the lateral edges of the neural plate...