... of neural crest-derived cranial bone progenitors. Down syndrome Craniofacial development Dyrk1a Neural crest Morphometrics Synchondroses Wellcome Trust http://dx.doi.org/10.13039/100010269 098327 098328 Biotechnology and Biological Sciences Research Council http...

...Phillip S. Ang; Matt J. Matrongolo; Maeson L. Zietowski; Shelby L. Nathan; Russell R. Reid; Max A. Tischfield ABSTRACT Craniofacial development requires precise spatiotemporal regulation of multiple signaling pathways that crosstalk to coordinate the growth and patterning of the skull...

...Idaliz M. Martínez Traverso; Jeffrey D. Steimle; Xiaolei Zhao; Jun Wang; James F. Martin ABSTRACT Hippo signaling, an evolutionarily conserved kinase cascade involved in organ size control, plays key roles in various tissue developmental processes, but its role in craniofacial development remains...

... regulates Sox9 expression during craniofacial development . J. Dent. Res. 100 , 406 - 414 . 10.1177/0022034520969109 Delhermite , J. , Tafforeau , L. , Sharma , S. , Marchand , V. , Wacheul , L. , Lattuca , R. , Desiderio , S. , Motorin , Y. , Bellefroid , E...

...Fangfang Yan; Peilin Jia; Hiroki Yoshioka; Akiko Suzuki; Junichi Iwata; Zhongming Zhao ABSTRACT Craniofacial development is regulated through dynamic and complex mechanisms that involve various signaling cascades and gene regulations. Disruption of such regulations can result in craniofacial birth...

...Martha L. Echevarría-Andino; Benjamin L. Allen ABSTRACT The Hedgehog (HH) pathway controls multiple aspects of craniofacial development. HH ligands signal through the canonical receptor PTCH1, and three co-receptors: GAS1, CDON and BOC. Together, these co-receptors are required during embryogenesis...

... on both normal and disordered craniofacial development in FaceBase, all freely available to the research community on the FaceBase Hub website. The Hub has developed numerous visualization and analysis tools designed to promote integration of multidisciplinary data while remaining dedicated to the FAIR...

.... FGF Notch Craniofacial development Enthesis Perichondrium Tendon Mouse Body movement requires tendons to deliver high tensile forces from skeletal muscle to bone. As tendon and bone have vastly different physical properties, a transitional connective tissue called the enthesis allows...

... craniofacial development, but the molecular role of MOZ in this context is unclear. Using genetic interaction and genomic studies, we have investigated the effects of loss of MOZ on the gene expression program during mouse development. Among the more than 500 genes differentially expressed after loss of MOZ...

... insights into the ancestral mechanisms involved in neural crest patterning. Lamprey Pharynx Cartilage Cranial ganglia Head skeleton Craniofacial development Vertebrate evolution A key event in early vertebrate evolution was the transition from a sessile, filter-feeding lifestyle to one...

...://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: The FaceBase Consortium is a dynamic, comprehensive resource of craniofacial development, with hundreds of datasets...

... 2016 Summary: Conditional ablation of Yap and Taz in the cranial neural crest reveals how these proteins regulate Fox gene expression and, in turn, cranial neural crest diversification and development. Yap and Taz Cranial neural crest Craniofacial development The neural crest (NC...

... is identified as an immediate downstream target of endothelin and is part of a positive-feedback mechanism for endothelin induction in the neural crest. Endothelin MEF2C Craniofacial development Melanocytes Neural crest Transcription Mouse The Endothelin signaling pathway triggers several...

... Summary: BMP signaling levels control p53-mediated apoptosis through SMAD1/5 phosphorylation and MDM2-p53 complex formation in cranial neural crest cells, regulating nasal cartilage morphogenesis. BMP SMAD Craniofacial development Neural crest cell p53 MDM2 Apoptosis Nasal septum...

... BMP SHH Cleft lip and palate Craniofacial development Facial fusion Chick Mouse Morphogenesis of the face is a complex process that involves iterative signaling between epithelial and mesenchymal cells. These interactions establish domains of directional growth that ultimately sculpt...

... in craniofacial development and embryonic survival, altering Hand1 phosphoregulation, and consequently Hand1 dimerization affinities, in NCCs results in severe mid-facial clefting and neonatal death. Hand1 phosphorylation mutants exhibit a non-cell-autonomous increase in pharyngeal arch cell death accompanied...

... in Hox-negative cranial NCCs induces abnormalities in structures derived from midbrain and forebrain Hox-negative NCCs, such as most of the jaw, facial and skull bones, supporting the notion that ectopic Hox gene expression interferes with normal craniofacial development (e.g. Couly et al., 1998...

.... * Author for correspondence ( maxime.bouchard@mcgill.ca ) Competing interests statement The authors declare no competing financial interests. 12 6 2013 © 2013. Published by The Company of Biologists Ltd 2013 LAR phosphatases Craniofacial development Bmp Wnt Pierre...

... lead to craniofacial defects. * Author for correspondence ( eldad.tzahor@weizmann.ac.il ) Competing interests statement The authors declare no competing financial interests. 7 2 2011 © 2011. 2011 Cranial neural crest Craniofacial development Epithelial-mesenchymal...

...-binding activity was required for later steps in craniofacial development, we crossed Hand2 EDE/+ mice with mice heterozygous for a deletion of the Hand2 enhancer that directs expression in the first and second branchial arches, referred to as Hand2 BA mice( Yanagisawa et al., 2003 ). Homozygous...