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Keywords: Costal2
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Journal Articles

Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling

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Laurent Ruel, Armel Gallet, Sophie Raisin, Arnaud Truchi, Laurence Staccini-Lavenant, Alexandra Cervantes, Pascal P. Thérond
Journal: Development
Development (2007) 134 (20): 3677–3689.
https://doi.org/10.1242/dev.011577
Published: 15 October 2007
..., the mechanism of Hh signal transduction is still poorly understood. In this study, we analyse the regulation of the kinesin-like protein Costal2 (Cos2) by Hh. We show that a residue on Cos2,serine 572 (Ser572), is necessary for normal transduction of the Hh signal from the transmembrane protein Smoothened (Smo...
View articletitled, Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling
Open the PDF for Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling in another window
Includes: Supplementary data
Journal Articles

Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused

Open Access
Karen S. Ho, Kaye Suyama, Matthew Fish, Matthew P. Scott
Journal: Development
Development (2005) 132 (6): 1401–1412.
https://doi.org/10.1242/dev.01689
Published: 15 March 2005
... the transcription of target genes decapentaplegic ( dpp ), patched ( ptc ) and engrailed ( en ) in a dose-responsive manner. Two key components of the Hh signal transduction machinery are the kinesin-related protein Costal2 (Cos2) and the nuclear protein trafficking regulator Suppressor of Fused [Su(fu)]. Both...
View articletitled, Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused
Open the PDF for Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused in another window
Includes: Supplementary data
Journal Articles

A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo

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Shang Yew Tay, Philip W. Ingham, Sudipto Roy
Journal: Development
Development (2005) 132 (4): 625–634.
https://doi.org/10.1242/dev.01606
Published: 15 February 2005
... exception to this rule is the kinesin-like protein Costal2, which plays a central role in controlling the activity of the zinc-finger-containing transcriptional regulator, Cubitus interruptus that modulates all Hedgehog-dependent target gene expression, but whose involvement in Hedgehog signalling has...
View articletitled, A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
Open the PDF for A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo in another window