... attributed. Highlighted Article: A comprehensive transcriptional atlas of microglia development demonstrating that microglia are necessary for widespread cortical gene expression changes triggered by in utero inflammation. Microglia Cortical development Neuroinflammation Maternal immune...

... Pollard , K. S. , Salama , S. R. , Lambert , N. , Lambot , M. A. , Coppens , S. , Pedersen , J. S. , Katzman , S. , King , B. , Onodera , C. , Siepel , A. et al. ( 2006 ). An RNA gene expressed during cortical development evolved rapidly in humans . Nature...

...-of-function effect. Mechanistically, the variant interfered with the ability of BAIAP2 to localize to the cell membrane. These results suggest that the functions of BAIAP2 in the cytoskeleton, cell morphogenesis and migration are important for cortical development and for the pathogenesis of lissencephaly...

... the neurogenesis of late-born cortical fates in mouse brain by upregulating the microRNAs let-7, miR-99a/100 and miR-125b. Cortical development Neurogenesis Cell fate Notch miRNA Mouse National Institute of Neurological Disorders and Stroke http://dx.doi.org/10.13039/100000065 R21 NS101450...

... for calcium deregulation as a convergence point in the etiology of neurodevelopmental disorders. Calcium signaling Cortical development Neurodevelopmental disorders University of California, San Francisco http://dx.doi.org/10.13039/100008069 Sandler Foundation http://dx.doi.org...

... is essential during cortical development for the correct migration of newborn neurons and, hence, for proper cortical lamination. * Present address: Helmholtz Zentrum München, 85764 Neuherberg, Germany. ‡ These authors contributed equally to this work § These authors contributed equally...

... by The Company of Biologists Ltd 2022 Highlighted Article: De novo transcriptomic profiling of developing marsupial neocortex reveals precocious neural maturation relative to eutherians. Cortical development Marsupial brain Heterochrony Developmental timing Cortical transcriptome Corpus...

.... Cortical development Microcephaly Cell cycle Minor spliceosome U11 snRNA National Institutes of Health http://dx.doi.org/10.13039/100000002 R01NS102538 The complex higher-order functions carried out by the cortex, such as controlling motor and sensory functions as well...

.... Summary: The BMP antagonist Grem1 is expressed by committed deep-layer glutamatergic neurons in the embryonic mouse cortex. Grem1 conditional knockout mice display cortical and behavioral abnormalities. Grem1 BMP Cortical development Excitatory neuron Mouse Japan Society...

.... , Valence , S. , Pierre , B. S. , Oger , M. et al. ( 2013 ). Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly . Nat. Genet. 45 , 639 - 647 . 10.1038/ng.2613 Raj , B. and Blencowe , B. J. ( 2015 ). Alternative...

... understanding of the mechanisms by which these dynamic properties of the mitochondria support mitochondrial function, review their impact on human cortical development and highlight areas in need of further research. * Author for correspondence ( [email protected] ) Competing interests...

... in cKO and control cortices ( Fig. 3 A-E). These findings suggest that the deletion of Exosc10 might lead to an enhanced apoptosis or defect in neuronal differentiation in early cortical development, causing the observed brain microcephaly at the postnatal stage. References Afgan , E...

.... A. , Hanics , J. , Morris , C. V. , Fuzik , J. , et al. ( 2014 ). Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling . Nat. Commun.   5 , 4421 . 10.1038/ncomms5421 Alpár , A. , Di Marzo , V. and Harkany , T. ( 2016...

...., 2019 ), drop-seq is currently applicable only to poly(A)-RNAs and (2) library preps with <1000 cells display extremely poor coverage ( Faridani et al., 2016 ). Here, we provide a complete catalog of miRNA expression in neural progenitors and newborn neurons during cortical development...

...., 2012 ). However, an excess accumulation of ROS may lead to cytotoxic levels of oxidative stress and cause damage to cellular components. Future efforts towards unraveling additional key regulators of ROS will be essential for understanding oxidative stress and mammalian cortical development under...

...: Conditional knockout of p75 NTR in mouse neuronal progenitors results in variable effects on the brain, including a marked decrease in brain volume and impaired thalamic midline closure. Brain development Cortical development Neuronal progenitor survival Thalamic midline fusion P75 knockout mouse...

... (IPs) in early developing mouse neocortex produce neuronal clones of diverse sizes (1-12 cells), including multilayer clones; remarkably, ∼2/3 of early IP divisions lead to asymmetric cell death. Tbr2 Intermediate progenitors Mosaic analysis with double markers MADM Cortical development...

... of disease pathogenesis underlying microcephaly in these syndromes, it is important to study the regulation of minor intron-containing genes (MIGs) in cortical development. University of Connecticut 10.13039/100007710 National Institute of Neurological Disorders and Stroke 10.13039...

...Mamunur Rashid; Judson Belmont; David Carpenter; Christopher E. Turner; Eric C. Olson Paxillin and Hic-5 are homologous focal adhesion adaptor proteins that coordinate cytoskeletal rearrangements in response to integrin signaling, but their role(s) in cortical development are unknown. Here, we find...

... of the schizophrenia-associated gene Disc1 in the developing mouse and in vitro leads to impaired astrogenesis due to disrupted RAS/ERK signaling. DISC1 Astrogenesis RAS/MEK/ERK signaling MAP kinase RASSF7 Cortical development National Basic Research Program of China 10.13039/501100002855...