... the neurogenesis of late-born cortical fates in mouse brain by upregulating the microRNAs let-7, miR-99a/100 and miR-125b. Cortical development Neurogenesis Cell fate Notch miRNA Mouse National Institute of Neurological Disorders and Stroke http://dx.doi.org/10.13039/100000065 R21 NS101450...

... for calcium deregulation as a convergence point in the etiology of neurodevelopmental disorders. Calcium signaling Cortical development Neurodevelopmental disorders University of California, San Francisco http://dx.doi.org/10.13039/100008069 Sandler Foundation http://dx.doi.org...

... is essential during cortical development for the correct migration of newborn neurons and, hence, for proper cortical lamination. Our motif activity analysis of NeuroD1-mediated active sites revealed that Tcf12 was highly enriched at induced sites that showed expression kinetics similar to NeuroD1 during...

... by The Company of Biologists Ltd 2022 Highlighted Article: De novo transcriptomic profiling of developing marsupial neocortex reveals precocious neural maturation relative to eutherians. Cortical development Marsupial brain Heterochrony Developmental timing Cortical transcriptome Corpus...

... and form the appropriate synaptic partners. Thus, proper cortical function requires proper cortical development. Early brain development requires a precise balance of progenitor cell amplification and neurogenesis, placing cell cycle regulation at the core of cortical development and disease ( Dehay...

... is expressed by committed deep-layer glutamatergic neurons in the embryonic mouse cortex. Grem1 conditional knockout mice display cortical and behavioral abnormalities. Grem1 BMP Cortical development Excitatory neuron Mouse Japan Society for the Promotion of Science http://dx.doi.org...

.... , Lebrun , N. , Jagline , H. , Muraca , G. , Saillour , Y. et al. ( 2018 ). Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development . Hum. Mol. Genet. 27 , 224 - 238 . 10.1093/hmg/ddx384 Buljan , M. , Chalancon , G...

... understanding of the mechanisms by which these dynamic properties of the mitochondria support mitochondrial function, review their impact on human cortical development and highlight areas in need of further research. The process of cristae dynamics and remodeling modulates the reaction kinetics of the citric...

... and normal cortical histogenesis. The neocortex of the mammalian brain is radially structured into six neuronal layers and multiple functional domains that form the structural basis for sensorimotor processing and intellectual ability. In early cortical development, apical progenitors (APs...

... organoids via cannabinoid CB 1 receptor activation. Cortical development Endocannabinoids Neurogenesis Projection neuron Tetrahydrocannabinol 2-Arachidonoylglycerol Cerebral organoid European Regional Development Fund 10.13039/501100008530 PI18-00941 BFU2017-83292-R...

... miRNAs involved in cortical development allowing us to describe for the first time the functional effects of interfering with the activity of miR-486a/b. Here, we provide a complete catalog of miRNA expression in neural progenitors and newborn neurons during cortical development and validate our...

.... Similar methods and materials were used to conduct RNA-seq differential expression analysis on wild-type VZ tissue at E11.5, E13.5, E15.5 and E17.5 to further understand ROS-related pathways during cortical development. Forty well-established genes known to regulate ROS level with P <0.05 were used...

...: Conditional knockout of p75 NTR in mouse neuronal progenitors results in variable effects on the brain, including a marked decrease in brain volume and impaired thalamic midline closure. Brain development Cortical development Neuronal progenitor survival Thalamic midline fusion P75 knockout mouse...

... potential by neural progenitors during cerebral cortical development . Development   127 , 2863 - 2872 . Eckler , M. J. , Nguyen , T. D. , McKenna , W. L. , Fastow , B. L. , Guo , C. , Rubenstein , J. L. R. and Chen , B. ( 2015 ). Cux2-positive radial glial cells...

... of Pax6 + and Tbr2 + cell quantification across mutant cortical development, statistical significance was determined by one-way ANOVA, followed by the post hoc Tukey test ( Table S8 ). For comparisons between the γH2AX + , p53 + or CC3 + subpopulation and all 4′,6-diamidino-2-phenylindole-positive...

...Mamunur Rashid; Judson Belmont; David Carpenter; Christopher E. Turner; Eric C. Olson Paxillin and Hic-5 are homologous focal adhesion adaptor proteins that coordinate cytoskeletal rearrangements in response to integrin signaling, but their role(s) in cortical development are unknown. Here, we find...

... modulation of MEK/ERK signaling ( Fig. 7 ). Fig. 7. A model of DISC1 function in astrogenesis during cortical development. DISC1 activates the RAS/MEK/ERK signaling pathway by direct association with RASSF7 and modulates astrogenesis in the embryonic brain. Fig. 7. A model of DISC1 function...

... development, the Arp2/3 actin branching complex regulates process formation and the maintenance of radial glial cell polarity, as well as affecting neuronal migration. Arp2/3 complex Actin Cortical development Neurogenesis Neuronal migration Radial glia Mouse During embryonic neurogenesis...

... for normal cortical development. References Artegiani , B. , Lindemann , D. and Calegari , F. ( 2011 ). Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brain . J. Exp. Med.   208 , 937 - 948 . 10.1084/jem.20102167...

... precursors are influenced by embryonic thalamic axons . J. Neurosci. 21 , 201 - 214 . Desai A. R. , McConnell S. K. ( 2000 ). Progressive restriction in fate potential by neural progenitors during cerebral cortical development . Development 127 , 2863 - 2872 . Englund C...