... the two neocortices cross via the anterior commissure in monotremes and marsupials, eutherians evolved a new commissural route: the corpus callosum ( Suárez et al., 2014 , 2018 ). The mechanisms involved in such evolutionary innovations remain largely unknown, but likely include changes in developmental...

...Noelia S. De León Reyes; Lorena Bragg-Gonzalo; Marta Nieto ABSTRACT The corpus callosum (CC) connects the cerebral hemispheres and is the major mammalian commissural tract. It facilitates bilateral sensory integration and higher cognitive functions, and is often affected in neurodevelopmental...

... neuronal connections via selective axon guidance. The EMX transcription factors are essential for early patterning of the cerebral cortex, but whether EMX1 mediates interhemispheric connectivity by controlling corpus callosum formation remains unclear. Here, we demonstrate that in mice on the C57Bl/6...

... the connectivity between thalamus and cortex and neuronal tangential migration in the basal telencephalon. Here, we show that COUP-TFI is required for proper axonal growth and guidance of all major forebrain commissures. Fibres of the corpus callosum, the hippocampal commissure and the anterior commissure project...

... pathfinding and cortical interneuron migration. Axon pathfinding defects included dysgenesis of the corpus callosum and hippocampal commissure, and abnormalities in corticothalamic and thalamocortical targeting. Slit2 and Slit1/2 double mutants display malformations in callosal development...

.... Further evidence for the role of the sling in callosal axon pathfinding came from two types of experiments; ablation of the sling in utero which resulted in agenesis of the corpus callosum, and rescue of the sling in vivo in surgically induced acallosal animals( Silver et al., 1982 ; Silver and Ogawa...