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Keywords: Convergent extension
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Journal Articles
Journal: Development
Development (2023) 150 (14): dev201630.
Published: 13 July 2023
... known as convergent extension (CE) ( Nikolopoulou et al., 2017 ; Wang et al., 2019 ). Mutations in genes encoding the core planar cell polarity (PCP) proteins, including cadherin EGF LAG seven-pass G-type receptor-1 ( Celsr1 ) ( Curtin et al., 2003 ), frizzled class receptor 3/6 ( Fzd3 / 6 ) ( Wang et...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (13): dev200358.
Published: 1 July 2022
...-of-function experiments, we examine the roles of convergent extension and apical constriction, and define the role of the surface ectoderm during NTC. We show that NTC is a two-stage process with distinct spatiotemporal contributions of convergent extension and apical constriction at each stage. Convergent...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (7): dev152488.
Published: 29 March 2018
... by actomyosin-based oriented cell rearrangement and resulting dynamic tissue reshaping (convergent extension, CE). By labeling clusters of cells spanning the entire heart primordia, we show that the heart primordia converge toward the midline to form a narrow tube, while extending perpendicularly to rapidly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev152488.
Published: 29 March 2018
... by actomyosin-based oriented cell rearrangement and resulting dynamic tissue reshaping (convergent extension, CE). By labeling clusters of cells spanning the entire heart primordia, we show that the heart primordia converge toward the midline to form a narrow tube, while extending perpendicularly to rapidly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3766–3776.
Published: 15 October 2017
... of the prosensory domain during development of the mouse cochlea. Inner ear Cochlear development Convergent extension Radial intercalation Live imaging Mouse The cellular mosaic that comprises the mammalian auditory sensory epithelium – the organ of Corti (OC) – is a remarkable example...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3766–3776.
Published: 15 October 2017
... Cochlear development Convergent extension Radial intercalation Live imaging Mouse National Institute on Deafness and Other Communication Disorders 10.13039/100000055 DC000059 The cellular mosaic that comprises the mammalian auditory sensory epithelium – the organ of Corti (OC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1725–1734.
Published: 1 May 2017
... during convergent extension in the Drosophila embryo. These studies demonstrate that planar polarity is rapidly established in a spatiotemporally regulated pattern that is dynamically remodeled in response to changes in cell orientation. These findings reveal an unexpected plasticity that maintains...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (4): 552–566.
Published: 15 February 2017
... malformations – ‘neural tube defects’ – that result when closure fails. The process of neural tube closure is complex and involves cellular events such as convergent extension, apical constriction and interkinetic nuclear migration, as well as precise molecular control via the non-canonical Wnt/planar cell...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (4): 552–566.
Published: 15 February 2017
... malformations – ‘neural tube defects’ – that result when closure fails. The process of neural tube closure is complex and involves cellular events such as convergent extension, apical constriction and interkinetic nuclear migration, as well as precise molecular control via the non-canonical Wnt/planar cell...
Journal Articles
Journal: Development
Development (2015) 142 (8): 1516–1527.
Published: 15 April 2015
...Philipp Andre; Hai Song; Wantae Kim; Andreas Kispert; Yingzi Yang Mesoderm formation and subsequent anterior-posterior (A-P) axis elongation are fundamental aspects of gastrulation, which is initiated by formation of the primitive streak (PS). Convergent extension (CE) movements and epithelial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (6): 1262–1271.
Published: 15 March 2013
..., cooperate to control PCP in the early mouse embryo. Two aspects of planar polarity can be analyzed quantitatively at cellular resolution in the mouse embryo: convergent extension of the axial midline; and posterior positioning of cilia on cells of the node. Analysis of the spatial distribution of brachyury...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Series: Primer Series
Development (2012) 139 (21): 3897–3904.
Published: 1 November 2012
...Masazumi Tada; Carl-Philipp Heisenberg Body axis elongation represents a common and fundamental morphogenetic process in development. A key mechanism triggering body axis elongation without additional growth is convergent extension (CE), whereby a tissue undergoes simultaneous narrowing...
Journal Articles
Journal Articles
Journal: Development
Development (2011) 138 (7): 1321–1327.
Published: 1 April 2011
... RACK1 as a novel interaction partner of PTK7, a regulator of planar cell polarity that is necessary for neural tube closure. RACK1 is likewise required for Xenopus neural tube closure. Further, explant assays suggest that PTK7 and RACK1 are required for neural convergent extension. Mechanistically...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (22): 3801–3811.
Published: 15 November 2010
... the following morphogenetic mechanisms: (1) convergent extension in the neural plate (NP); (2) cell wedging along the anterior NP border; and (3) autonomous in-plane deformations outside the NP. Our numerical predictions agree relatively well with the observed morphology, as well as with our measured stress...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (3): 417–426.
Published: 1 February 2010
... in mesendoderm induction and gastrulation movements. Nodal activity is necessary for convergent extension in axial mesoderm and for head mesoderm migration. Using morpholino-mediated knockdown, we found that the Nodal ligands Xnr5 and Xnr6 are together required for mesendoderm induction, whereas Xnr1 and Xnr2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (20): 3463–3474.
Published: 15 October 2009
... intercalation. Collectively, our data suggest that the distinct morphological features of the proliferative chondrocytes result from a convergent extension-like process that is regulated independently of chondrocyte maturation. Skeletons were prepared as described( McLeod, 1980 ). Briefly,dissected hindlimbs...
Includes: Supplementary data