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Keywords: Contractility
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Journal Articles
Journal: Development
Development (2023) 150 (21): dev201811.
Published: 3 November 2023
... by Smad6 deletion in endothelial cells in vivo . At the cellular level, co-depletion of Smad6 and Alk1 rescued the destabilized junctions and impaired barrier function of endothelial cells depleted for SMAD6 alone. Mechanistically, blockade of actomyosin contractility or increased PI3K signaling rescued...
Includes: Supplementary data
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Reproductive biology
Journal: Development
Development (2023) 150 (6): dev201099.
Published: 23 March 2023
... in the syncytial germline and oocytes. A 60% reduction in the level of CAP-1 caused a twofold increase in F-actin and non-muscle myosin II activity, and laser incision experiments revealed an increase in rachis contractility. Cytosim simulations pointed to increased myosin as the main driver of increased...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199691.
Published: 22 October 2021
... reveals mild morphogenetic defects and progressive cardiomegaly, and that Lamb1a functions to limit heart size during cardiac development by restricting SHF addition. lamb1a mutants exhibit hallmarks of altered haemodynamics, and blocking cardiac contractility in lamb1a mutants rescues heart size...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev155325.
Published: 24 April 2018
... the two is unclear, because actomyosin-enriched boundaries are not necessarily associated with folds. Also, some cases of epithelial folding occur independently of actomyosin contractility. We investigated the shallow folds called parasegment grooves that form at boundaries between anterior and posterior...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4249–4260.
Published: 1 December 2017
... and mathematical modeling has changed our understanding of morphogenesis – the shaping of an organism during development. Emerging evidence suggests that the subcellular organization of contractile cytoskeletal networks plays a key role in force generation, while on the tissue level the spatial organization...
Journal Articles
Journal: Development
Development (2014) 141 (9): 1789–1793.
Published: 1 May 2014
...Akankshi Munjal; Thomas Lecuit Tissue morphogenesis is driven by coordinated cellular deformations. Recent studies have shown that these changes in cell shape are powered by intracellular contractile networks comprising actin filaments, actin cross-linkers and myosin motors. The subcellular forces...
Journal Articles
Journal: Development
Development (2006) 133 (18): 3507–3516.
Published: 15 September 2006
... actin-dependent processes such as cortex ruffling and pseudocleavage furrow formation. Thus, contractile polarity was not established ( Fig. 5 ). The embryos also failed to extrude the polar bodies (data not shown) and cytokinesis failed, as has been previously shown( Jantsch-Plunger et al.,2000...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (12): 2837–2848.
Published: 15 June 2005
... for embryonic development. ANI-1 is essential for cortical ruffling and pseudocleavage, contractile events that occur in embryos prior to mitosis. ANI-1 is also required for the highly asymmetric cytokinetic events that extrude the two polar bodies during oocyte meiosis,but is dispensable for cytokinesis...
Includes: Multimedia, Supplementary data