... this is being applied to investigating regeneration of the diseased heart. Heart development Gene regulation Congenital heart disease Regeneration The heart is an organ that captivates. We feel its incessant beating, it is the beacon of life and it symbolizes love. It is also the first organ...

...Julie L. M. Moreau; Scott Kesteven; Ella M. M. A. Martin; Kin S. Lau; Michelle X. Yam; Victoria C. O'Reilly; Gonzalo del Monte-Nieto; Antonio Baldini; Michael P. Feneley; Anne M. Moon; Richard P. Harvey; Duncan B. Sparrow; Gavin Chapman; Sally L. Dunwoodie ABSTRACT Congenital heart disease (CHD...

...Saurabh S. Kulkarni; Mustafa K. Khokha ABSTRACT Congenital heart disease (CHD) is a major cause of infant mortality and morbidity, yet the genetic causes and mechanisms remain opaque. In a patient with CHD and heterotaxy, a disorder of left-right (LR) patterning, a de novo mutation was identified...

.... Zebrafish Cardiac progenitors Second heart field Outflow tract Congenital heart disease nkx2.5 During mammalian embryogenesis, cardiac progenitor cells in the anterior second heart field (SHF) produce the right ventricle and embryonic outflow tract (OFT) through late differentiation...

... biogenesis and resorption at this organ. We recently identified a mutation affecting NEK2 , a member of the NIMA-like serine-threonine kinase family, in a patient with congenital heart disease associated with abnormal LR development. Here, we report how Nek2 acts through cilia to influence LR patterning...

... development Proliferation Cardiomyocyte Congenital heart disease First heart field Second heart field CASZ1 Mouse Early development of the heart is governed by hyperplastic growth, in which cardiac cells undergo mitogen-dependent activation during the G1 phase of the cell cycle ( Ahuja et al...

... to understanding the process of cardiac development and the pathology associated with human congenital heart disease. Here, we show that the cardiac transcription factor CASTOR (CASZ1) directly interacts with congenital heart disease 5 protein (CHD5), which is also known as tryptophan-rich basic protein (WRB...

... of cardiac septal and valvular tissues thus has important implications for the diagnosis, prevention and treatment of congenital heart disease. The development of heart septa and valves involves multiple types of progenitor cells that arise either within or outside the heart. Here, we review...

... for correspondence (e-mail: scott.baldwin@Vanderbilt.edu ) 30 8 2006 © 2006. 2006 Tgfβ Cardiogenesis AV remodeling DILV Congenital heart disease Mouse Congenital heart diseases (CHDs) occur in as many as 1% of newborns, and are the leading cause of infant morbidity and mortality...

... of primary and anterior heart field-derived structures rely on Fgf8 signals from discrete temporospatial domains. * Author for correspondence (e-mail: anne.moon@genetics.utah.edu ) 16 3 2006 © 2006. 2006 Fgf8 Cardiovascular Outflow tract Congenital heart disease Truncus...

... lead to congenital heart disease (CHD). We have genetically defined a novel conserved tyrosine-rich domain (YRD) within Nkx2-5 that has co-evolved with its homeodomain. Mutation of the YRD did not affect DNA binding and only slightly diminished transcriptional activity of Nkx2-5 in a context-specific...

...Karoline J. Briegel; H. Scott Baldwin; Jonathan A. Epstein; Alexandra L. Joyner Partial trisomy 2p syndrome includes a spectrum of congenital heart disease(CHD) that is characterized by complex malformations of the outflow and inflow tracts, defects in cardiac septation, heart position, as well...

...-mail: anne.moon@genetics.utah.edu ) 4 9 2003 © The Company of Biologists Limited 2003 2003 Cardiovascular development Pharyngeal arch FGF8 Endoderm Heart field Pharyngeal arch artery Congenital heart disease Vasculogenesis Aortic arch Outflow tract Coronary artery Thymus Parathyroid...

... FGF8 Pharyngeal arch artery Congenital heart disease Truncus arteriosus Interrupted aortic arch Outflow tract Endoderm Immunodeficiency Pharyngeal arches are transient bulges of tissue in the neck of vertebrate embryos consisting of mesenchyme separated by membranous clefts in which...

... ). Transgenic mice Congenital heart disease Persistent truncus arteriosus Neural tube defects Spina bifida Epaxial muscle Hypaxial muscle Diaphragm Neural crest In this study, we have addressed the cell autonomy of Pax3 function in neural crest by engineering transgenic mice lacking Pax3...