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Keywords: Congenital heart disease
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Journal Articles
Journal: Development
Development (2020) 147 (21): dev194233.
Published: 21 October 2020
... this is being applied to investigating regeneration of the diseased heart. Heart development Gene regulation Congenital heart disease Regeneration The heart is an organ that captivates. We feel its incessant beating, it is the beacon of life and it symbolizes love. It is also the first organ...
Journal Articles
Journal: Development
Development (2019) 146 (4): dev172957.
Published: 20 February 2019
...Julie L. M. Moreau; Scott Kesteven; Ella M. M. A. Martin; Kin S. Lau; Michelle X. Yam; Victoria C. O'Reilly; Gonzalo del Monte-Nieto; Antonio Baldini; Michael P. Feneley; Anne M. Moon; Richard P. Harvey; Duncan B. Sparrow; Gavin Chapman; Sally L. Dunwoodie ABSTRACT Congenital heart disease (CHD...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev159889.
Published: 28 November 2018
...Saurabh S. Kulkarni; Mustafa K. Khokha ABSTRACT Congenital heart disease (CHD) is a major cause of infant mortality and morbidity, yet the genetic causes and mechanisms remain opaque. In a patient with CHD and heterotaxy, a disorder of left-right (LR) patterning, a de novo mutation was identified...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4616–4624.
Published: 15 December 2017
... and heart development in zebrafish, information that will be crucial for deciphering the cellular mechanisms underlying zebrafish models of human congenital disorders. Zebrafish Cardiac progenitors Second heart field Outflow tract Congenital heart disease nkx2.5 During mammalian...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (23): 4068–4079.
Published: 01 December 2015
... biogenesis and resorption at this organ. We recently identified a mutation affecting NEK2 , a member of the NIMA-like serine-threonine kinase family, in a patient with congenital heart disease associated with abnormal LR development. Here, we report how Nek2 acts through cilia to influence LR patterning...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (11): 2037–2047.
Published: 01 June 2015
... development Proliferation Cardiomyocyte Congenital heart disease First heart field Second heart field CASZ1 Mouse Early development of the heart is governed by hyperplastic growth, in which cardiac cells undergo mitogen-dependent activation during the G1 phase of the cell cycle ( Ahuja et al...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 3040–3049.
Published: 01 August 2014
... to understanding the process of cardiac development and the pathology associated with human congenital heart disease. Here, we show that the cardiac transcription factor CASTOR (CASZ1) directly interacts with congenital heart disease 5 protein (CHD5), which is also known as tryptophan-rich basic protein (WRB...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3277–3299.
Published: 15 September 2012
... of cardiac septal and valvular tissues thus has important implications for the diagnosis, prevention and treatment of congenital heart disease. The development of heart septa and valves involves multiple types of progenitor cells that arise either within or outside the heart. Here, we review...
Journal Articles
Journal: Development
Development (2006) 133 (22): 4585–4593.
Published: 15 November 2006
... haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development 121 , 1845 -1854. Hoffman, J. I. ( 1995 ). Incidence of congenital heart disease: II. Prenatal incidence. Pediatr. Cardiol 16 , 155 -165. Hoffman, J. I. and Kaplan, S. ( 2002 ). The incidence...
Journal Articles
Journal: Development
Development (2006) 133 (12): 2419–2433.
Published: 15 June 2006
... Fgf8 Cardiovascular Outflow tract Congenital heart disease Truncus Arteriosus Transposition 22q11 deletion syndrome Pharyngeal arches Neural crest DiGeorge syndrome Cardiogenesis requires specification, differentiation, proliferation and migration of cell populations...
Journal Articles
Journal: Development
Development (2006) 133 (7): 1311–1322.
Published: 01 April 2006
... lead to congenital heart disease (CHD). We have genetically defined a novel conserved tyrosine-rich domain (YRD) within Nkx2-5 that has co-evolved with its homeodomain. Mutation of the YRD did not affect DNA binding and only slightly diminished transcriptional activity of Nkx2-5 in a context-specific...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (14): 3305–3316.
Published: 15 July 2005
...Karoline J. Briegel; H. Scott Baldwin; Jonathan A. Epstein; Alexandra L. Joyner Partial trisomy 2p syndrome includes a spectrum of congenital heart disease(CHD) that is characterized by complex malformations of the outflow and inflow tracts, defects in cardiac septation, heart position, as well...
Journal Articles
Journal: Development
Development (2003) 130 (25): 6361–6374.
Published: 22 December 2003
... in congenital heart disease. Circulation 82 , 332 -340. Kirby, M. L. and Waldo, K. L. ( 1995 ). Neural crest and cardiovascular patterning. Circ. Res. 77 , 211 -215. Kirby, M. L., Turnage, K. L., 3rd and Hays, B. M. ( 1985 ). Characterization of conotruncal malformations following ablation...
Journal Articles
Journal: Development
Development (2002) 129 (19): 4591–4603.
Published: 01 October 2002
...-derived tissues. In either case, Fgf8 may function as a modifier of the 22q11 deletion and contribute to the phenotypic variability of this syndrome. 1 7 2002 © 2002. 2002 22q11 deletion syndromes Pharyngeal arches FGF8 Pharyngeal arch artery Congenital heart disease Truncus...