... R01HG003988 1R01HL120920-01 2P01HL134599 1R01 HL145060 HAND factors Cardiogenesis Congenital heart defects Endocardial development Mouse Highlighted Article: The bHLH transcription factor HAND2 regulates key gene regulatory networks within the developing endocardium and its DNA...

... and regenerative biological approaches to understanding the etiology of congenital heart defects and the repair of diseased cardiac tissue. In this Meeting Review, we present several of the major themes that were discussed throughout the meeting and highlight the depth and range of research currently being...

.... Congenital heart defects Daam1 Formin protein Heart development Cytoskeletal architecture Sarcomere organization Actin Planar cell polarity (PCP) Mouse Actin is one of the most highly conserved and abundant proteins in all eukaryotes ( Pollard and Cooper, 2009...

... ductus arteriosus and is one of the most common congenital heart defects. Mice with smooth muscle cell-specific deletion of Jag1 , which encodes a Notch ligand, die postnatally from patent ductus arteriosus. These mice exhibit defects in contractile smooth muscle cell differentiation in the vascular wall...

... was designed as a recessive screen, a number of the mutations showed cardiovascular phenotypes in both heterozygote and homozygote animals. These studies show the efficacy of ENU mutagenesis and high-throughput ultrasound phenotyping in recovering mutations causing a wide spectrum of congenital heart defects...