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Keywords: Conditional knockout
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Journal Articles
Journal: Development
Development (2023) 150 (1): dev201315.
Published: 5 January 2023
... Isl1 , at the chromosome 13 locus. Using single and double conditional knockout mice, we confirm the countervailing actions of each gene, and validate in vitro a crucial role for two single nucleotide polymorphisms in the 5′UTR of Isl1 , one of which yields a novel E-box, mediating the repressive...
Includes: Supplementary data
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Reproductive biology
Journal: Development
Development (2020) 147 (13): dev190371.
Published: 3 July 2020
..., but still both the TE and the primitive endoderm are host derived ( Nagy et al., 1993 ). Thus, any genetic modification in the host embryo is maintained not only in the trophoblast, but also in the primitive endoderm lineage. Although a large set of conditional knockout mouse models are available from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev156588.
Published: 8 January 2018
...-Golgin GMAP-210 reveals that the skeletal phenotype in achondrogenesis type-1A, which is caused by mutations in GMAP-210, is solely due to impaired protein trafficking by chondrocytes. GMAP-210 Achondrogenesis type 1A Conditional knockout Golgin Cartilage Proteomics The evolution...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3808–3818.
Published: 15 October 2017
... Presomitic mesoderm Paraxial mesoderm Conditional knockout Proteomic Mouse In mouse, the posterior part of the paraxial mesoderm, called presomitic mesoderm (PSM), generates a pair of somites every 2 h and plays crucial roles during vertebrate elongation ( Pourquié, 2011 ). This rhythmic process...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (6): 1342–1352.
Published: 15 March 2013
... ) * These authors contributed equally to this work Competing interests statement The authors declare no competing financial interests. 10 1 2013 © 2013. Published by The Company of Biologists Ltd Wnt1 Conditional knockout Dopamine neurons Genetic inducible fate mapping...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1507–1519.
Published: 15 April 2011
... chondrocyte-specific survival mechanisms by binding to the Pik3ca promoter, inducing Akt phosphorylation. To generate Sox9 conditional knockout mice, 11Enh-Cre transgenic mice, 11Prom-Cre transgenic mice ( Iwai et al., 2008 ) and Sox9 flox/flox mice ( Akiyama et al., 2002 ) were prepared and mated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (12): 2237–2249.
Published: 15 June 2007
... ) 3 4 2007 © 2007. 2007 Autonomic nervous system bHLH transcription factor Conditional knockout Enteric nervous system Gene knockout Gut development Mouse Basic helix-loop-helix (bHLH) transcription factors play important roles in lineage determination and differentiation...
Journal Articles
Journal: Development
Development (2006) 133 (9): 1725–1734.
Published: 1 May 2006
... by colonising the hindgut from the pelvic plexus in a caudorostral wave ( Kapur,2000 ; Druckenbrod and Epstein,2005 ). Enteric nervous system β1 integrins Neural crest Migration Conditional knockout Hirschsprung's disease Mouse © 2006. 2006 3 3 2006 * Present...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (22): 4927–4936.
Published: 15 November 2005
... expressing Cre-ERT2 can be efficiently used to perform time-specific excision of a target gene by a Cre/ loxP -based conditional knockout system(reviewed by Metzger et al.,2005 ). We tested the efficiency of the Cre-ERT2 recombinase in mediating excision at the Hoxa2 locus by directly monitoring...
Journal Articles
Journal: Development
Development (2005) 132 (22): 4987–4998.
Published: 15 November 2005
... contributed equally to this work 14 9 2005 ©2005. 2005 Nkx2.1 Parvalbumin Somatostatin Conditional knockout Smoothened Cell fate determination in the cerebral cortex is a crucial field of study due to its relevance to mental and neurological illnesses. GABAergic interneurons...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (16): 3871–3883.
Published: 15 August 2004
... Street, 1001 PCTB, Baltimore, MD 21205, USA 30 4 2004 ©2004. 2004 Integrin Peripheral nervous system Neural crest cells Conditional knockout The ontogeny of neural crest cells (NCC) is a major morphogenetic process involving various biological steps, such as epithelium...