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Keywords: Computational modeling
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Journal Articles
Journal: Development
Development (2022) 149 (23): dev199842.
Published: 7 December 2022
.... This variety of responses relies on a conserved signaling pathway. Its logic includes a negative-feedback loop involving the Hh receptor Ptc. Here, using experiments and computational models we study and compare the different spatial signaling profiles downstream of Hh in several developing Drosophila organs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199726.
Published: 20 January 2022
... found that pressure activates RA signaling through the mechanosensor Yap. A computational model predicts that mechanical signaling through Yap and RA affects lung branching by altering the balance between epithelial proliferation and smooth muscle wrapping, which we test experimentally. Our results...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev162578.
Published: 17 October 2018
... to multiscale pulsatile computational models. We combine experimental-based computational models of multiple PAAs to quantify hemodynamic forces in the rapidly morphing Hamburger Hamilton (HH) stage HH18, HH24 and HH26 embryos. We identify local morphological variation along the PAAs and their association...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4158–4167.
Published: 1 November 2014
... clock network at different spatial locations have been proposed, the mechanism underlying traveling waves has remained elusive. Here, we combined molecular-level computational modeling and quantitative experimentation to solve this puzzle. Our model predicts the existence of an increasing gradient...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (15): 3244–3253.
Published: 1 August 2013
... the only conserved oscillating genes in all analyzed vertebrate species. Hes/Her proteins form dimers and negatively autoregulate their own transcription. Here, we developed a stochastic two-dimensional multicellular computational model to elucidate how the dynamics, i.e. period, amplitude...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1680–1690.
Published: 1 May 2012
...: to serve as a mechanically passive substrate for the crawling mesoderm and to secrete various growth factors necessary for cardiac specification and differentiation. Here, using computational modeling and experiments on chick embryos, we present evidence supporting an active mechanical role...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (1): 47–56.
Published: 1 January 2012
... is difficult to examine in vivo. To address this difficulty we built, as a test case, a cell-centered state-based computational model of key behaviors that govern germline development in C. elegans , and used it to drive simulations of cell population dynamics under a variety of perturbations. Our analysis...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (22): 3801–3811.
Published: 15 November 2010
...) is the first step in this cascading sequence of out-of-plane tissue folds. The HF establishes the anterior extent of the embryo and initiates heart, foregut and brain development. Here, we use a combination of computational modeling and experiments to determine the physical forces that drive HF formation...
Includes: Multimedia, Supplementary data