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Keywords: Competence
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Journal Articles
Journal: Development
Development (2019) 146 (7): dev172916.
Published: 03 April 2019
... confirm that naïve PSCs do not respond directly to germ layer induction, but must first acquire competence. Capacitation for multi-lineage differentiation occurs without exogenous growth factor stimulation and is facilitated by inhibition of Wnt signalling. Whole-transcriptome profiling during this...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (5): dev158832.
Published: 06 March 2018
...Pavel Vopalensky; Sabrina Pralow; Nadine L. Vastenhouw ABSTRACT The activation of specific gene expression programs depends on the presence of the appropriate signals and the competence of cells to respond to those signals. Although it is well established that cellular competence is regulated in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3263–3273.
Published: 01 October 2015
... control photoreceptor cell fate specification. * Author for correspondence ( tomreh@uw.edu ) Competing interests The authors declare no competing or financial interests. © 2015. Published by The Company of Biologists Ltd 2015 Summary: This Review discusses recent progress in the...
Journal Articles
Journal: Development
Development (2013) 140 (9): 1936–1945.
Published: 01 May 2013
... genetic lineage tracing method, and genetic data, we show that the competence to embark on a neuronal or sensory fate is provided sequentially and very early during otic placode induction. Loss of Foxi1 prevents neuronal precursor formation without affecting hair cell specification, whereas loss of Dlx3b...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (4): 657–666.
Published: 15 February 2012
...Johnny J. Touma; Frank F. Weckerle; Michael D. Cleary Similar to mammalian neural progenitors, Drosophila neuroblasts progressively lose competence to make early-born neurons. In neuroblast 7-1 (NB7-1), Kruppel (Kr) specifies the third-born U3 motoneuron and Kr misexpression induces ectopic U3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (12): 2591–2600.
Published: 15 June 2011
...Hidehiko Hashimoto; Takashi Enomoto; Gaku Kumano; Hiroki Nishida In embryos of the ascidian Halocynthia roretzi , the competence of isolated presumptive notochord blastomeres to respond to fibroblast growth factor (FGF) for induction of the primary notochord decays by 1 hour after cleavage from the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (9): 1421–1430.
Published: 01 May 2010
... the absence of endogenous Hunchback. Previous studies have shown that Hunchback can specify early-born neuronal identity and maintain ‘young’ neural progenitor (neuroblast) competence. We identify two conserved domains required for Hunchback-mediated transcriptional repression, and show that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (24): 4165–4177.
Published: 15 December 2008
... tube and epidermis. Here, Dlx3, Dlx5, Pax6 and the pan-neuronal marker Hu serve as molecular labels to follow the maturation of olfactory precursors over time. When competence to form olfactory placode was tested by grafting ectoderm from different axial levels to the anterior neural fold, we found...
Journal Articles
Journal: Development
Development (2008) 135 (2): 249–258.
Published: 15 January 2008
...-field specification in vertebrates (as it is in Drosophila ). This concept is also consistent with classical embryological studies of many organ systems involving a `multiple-step induction'. Competence Genomics Induction Lens Notch Xenopus Although many signaling factors and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (13): 2449–2458.
Published: 01 July 2007
... origins in different tissues. Excess RA leads to ectopic foxi1 expression throughout the entire preplacodal domain. Foxi1 provides competence to adopt an otic fate. Subsequently, pax8 , the expression of which depends upon Foxi1 and Fgf, is also expressed throughout the preplacodal domain. By contrast...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (11): 2041–2050.
Published: 01 June 2007
... region when Bmp or Fgf signaling was blocked just before hepatic specification. However, hhex and prox1 expression in adjacent endodermal and mesodermal tissues appeared unaffected by these manipulations. Additional genetic studies indicate that the endoderm maintains competence for Bmp-mediated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (5): 877–887.
Published: 01 March 2006
...-placodal domain. By contrast, ectoderm from outside this domain is not competent to express otic markers in response to Fgfs. Grafting naïve ectoderm into the pre-placodal domain causes upregulation of pre-placodal markers within 8 hours, together with the acquisition of competence to respond to Fgf...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2657–2668.
Published: 15 June 2003
...Andrew D. Chalmers; Bernhard Strauss; Nancy Papalopulu A key feature of early vertebrate development is the formation of superficial, epithelial cells that overlie non-epithelial deep cells. In Xenopus , deep and superficial cells show a range of differences,including a different competence for...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (16): 3873–3885.
Published: 15 August 2002
... Muscle patterning Chick/quail Experimental embryology Somite Dermatome Competence Confocal microscopy Epaxial Stem cell Progenitor cell Asymmetry The epaxial myotome, the earliest skeletal muscle tissue to appear during avian and mammalian embryonic development, arises from progenitor...
Journal Articles
Journal: Development
Development (2002) 129 (4): 917–933.
Published: 15 February 2002
... suggest that spg / pou2 is a transcription factor that mediates regional competence to respond to Fgf8 signaling. *Author for correspondence (e-mail: brand@mpi-cbg.de ) 27 11 2001 © 2002. 2002 Competence Fgf8 pou2 Oct3/4 Pou5f1 MHB Isthmus pax2 spiel-ohne-grenzen...
Journal Articles
Journal: Development
Development (2002) 129 (1): 83–93.
Published: 01 January 2002
... centers that pattern neighboring fields to create molecularly distinct domains. We investigated the mechanisms underlying the regionally distinct competence for two such organizing signals, Fibroblast growth factor 8 (Fgf8) and Sonic hedgehog (Shh), using chick embryos. First, we demonstrated that FGF...
Journal Articles
Journal: Development
Development (2001) 128 (23): 4789–4800.
Published: 01 December 2001
...-hindbrain boundary (MHB) and for conferring competence to the anterior neuroectoderm in responding to forebrain-, midbrain- and rostral hindbrain-inducing activities. We are deeply indebted with Gail Martin for the generous gift of the Gbx2 mutant strain. We thank Gail Martin and Ivor Mason for...
Journal Articles
Journal: Development
Development (1989) 107 (Supplement): 141–148.
Published: 01 April 1989
.... Above the induction threshold there is a progressive increase of muscle formation with dose. Single blastula ectoderm cells can be induced and will differentiate in a defined medium to form mesodermal tissues. All inner blastula cells are competent to respond to the factors but outer cells, bearing...
Journal Articles
Journal: Development
Development (1985) 89 (Supplement): 333–347.
Published: 01 November 1985
... which only support the pathway of differentiation already in progress. Inductive interactions therefore refer to pluripotential systems which are open to a choice of potential Key words: inductive interaction, competence, determination, amphibia. 334 P. D. NIEUWKOOP pathways. It must be realised that an...