... or the Mirror transcription factor induce a transformation of dorsal head structures into ectopic eyes and antennae. Eye-antennal disc Dorsal-ventral patterning Compartments Mirror Twin of Eyeless Wingless Robert Briggs Fellowship in Developmental Biology National Eye Institute...

... compartments ( Fraser et al., 1990 ; Jimenez-Guri et al., 2010 ; Kiecker and Lumsden, 2005 ). This compartmentalization involves the formation of a cellular interface between segments called the hindbrain boundary ( Guthrie and Lumsden, 1991 ). At early stages of hindbrain segmentation, cells...

...Joanna Krzemień; Caroline C. G. Fabre; José Casal; Peter A. Lawrence In the past, segments were defined by landmarks such as muscle attachments, notably by Snodgrass, the king of insect anatomists. Here, we show how an objective definition of a segment, based on developmental compartments, can help...

.... We then searched for the engrailed -dependent agent responsible for these repellent properties. We found slit to be expressed in the P compartment and, using genetic mosaics, present evidence that Slit is the responsible molecule. Blocking the activity of the three Robo genes (putative receptors...

... , the developmental and growth parameters of which are well known. We have devised a method to generate entire fast-growing Minute + (M + ) discs or compartments in slow developing Minute/+ (M/+) larvae. Under these conditions, a M + wing disc gains at least 20 hours of additional development time. Yet it grows...

... Hedgehog and Decapentapelagic, but not Wingless, signaling. Additionally, squamous morphogenesis shifts the anteroposterior (AP) compartment boundary in the peripodial epithelium relative to the stationary AP boundary in the disc proper. Finally, by lineage tracing cells in the PE, we surprisingly find...

..., they suggest a new role for Chx10 in maintenance of compartment boundaries in the peripheral retina. Total RNA from E4 chicks was isolated using the Trizol reagent according to the manufacturer's instructions (Life Technologies) and cDNA was generated using superscript II reverse transcriptase (Life...

... to later neural subdivisions initially formed overlapping populations, but after stage 16+ they formed non-overlapping cell groups having characteristics of tissue `compartments', preceding development of morphologically distinct neural subdivisions. In early retinal development, a single compartment...

... that anterior and posterior somite domains are not lineage-restricted compartments with respect to distribution along the anteroposterior axis but support a ‘leaky’ resegmentation in development from somite to vertebral column. Alignment of somites with vertebrae suggests that the first two somites do...

...Myriam Zecca; Gary Struhl Growth and patterning of the Drosophila wing imaginal disc depends on its subdivision into dorsoventral (DV) compartments and limb (wing) and body wall (notum) primordia. We present evidence that both the DV and wing-notum subdivisions are specified by activation...

...Peter A. Lawrence; José Casal; Gary Struhl ABSTRACT Like the Drosophila embryo, the abdomen of the adult consists of alternating anterior (A) and posterior (P) compartments. However the wing is made by only part of one A and part of one P compartment. The abdomen therefore offers an opportunity...

...Peter A. Lawrence1; José Casal; Gary Struhl ABSTRACT The adult abdomen of Drosophila is a chain of anterior (A) and posterior (P) compartments. The engrailed gene is active in all P compartments and selects the P state. Hedgehog enters each A compartment across both its anterior and posterior edges...

.... Here we provide evidence that each primordium is divided into anterior and posterior compartments. Genes that are known to be expressed in compartment-specific manners in other discs ( engrailed, hedgehog, patched, decapentaplegic, wingless and cubitus interruptus ) are expressed in analogous patterns...

...Tetsuya Tabata; Carol Schwartz; Elizabeth Gustavson; Zehra Ali; Thomas B. Kornberg ABSTRACT Anterior/posterior compartment borders bisect every Drosophila imaginal disc, and the engrailed gene is essential for their function. We analyzed the role of the engrailed and invected genes in wing discs...

...’ phenotypes were associated with the loss of wingless expression; this loss may be partially or wholly responsible for the anti-proneural phenotype. Curiously, Notch − clones limited to the dorsal or ventral compartments could disrupt wingless expression and proneural development in the adjacent compartment...

...Carol Schwartz; John Locke; Craig Nishida; Thomas B. Kornberg ABSTRACT The cubitus interruptus (ci) gene of Drosophila is expressed in all anterior compartment cells in both embryos and imaginal disks where it encodes a putative zinc-finger protein related to the vertebrate Gli and C. elegans Tra-1...

...Eric Birgbauer; Scott E. Fraser ABSTRACT Previous cell lineage studies indicate that the repeated neuromeres of the chick hindbrain, the rhombomeres, are cell lineage restriction compartments. We have extended these results and tested if the restrictions are absolute. Two different cell marking...

...Seth S. Blair ABSTRACT The dorsoventral (D/V) lineage boundary in the developing wing disc of Drosophila restricts growing cells to the prospective dorsal or ventral compartments of the wing blade. This restriction appears along the prospective margin of the wing some time during the middle to late...

...Laurel A. Raftery; Michele Sanicola; Ronald K. Blackman; William M. Gelbart Imaginal disks, the primordia of the adult appendages in Drosophila , are divided into anterior and posterior compartments. However, the developmental role of such compartments remains unclear. The expression...

...Stephen J. Poole; Thomas B. Kornberg ABSTRACT The engrailed gene is required for segmentation of the Drosophila embryo and is expressed in cells constituting the posterior developmental compartments. In mutant embryos lacking engrailed function, portions of the cuticular pattern in each segment...