... or intermediate target. Using different animal models and in vivo , ex vivo and in vitro experiments, we provide evidence for a crucial role of primary cilium-mediated signaling in long-range axon guidance. The primary cilium on the cell body of commissural neurons transduces long-range guidance signals sensed...

... interneuron populations (dI1-dI6), three ventral interneuron populations (V0-V3) and a large number of motor neurons ( Helms and Johnson, 2003 ; Lai et al., 2016 ). The interneuron populations can reach ipsilateral or contralateral targets; these last neurons are known as commissural neurons. Their axons...

... maintained the stability of axonal Robo1 during Slit stimulation. We identified Arf6 guanosine triphosphatase and its activators, cytohesins, as previously unknown components in Slit-Robo1 signalling in vertebrate commissural neurons. Slit-Robo1 signalling activated Arf6. The Arf6 -deficient mice exhibited...

... mechanisms that shape the CNS/PNS interface are not well characterized. Here we show that netrin 1, which is secreted at the CNS basal lamina by neural precursor endfeet, prevents various populations of hindbrain commissural neurons, in particular pontine neurons, from migrating into the PNS through nerve...

... to severe defects in midline crossing of spinal cord axons. However, the mutants did not fully phenocopy loss of the netrin 1 receptor Unc5. Netrin-1 Axon guidance Commissural neurons Netrin 1 (Ntn1) is a secreted molecule of the laminin superfamily ( Ishii et al., 1992 ) that is best known...

...Yasuyuki Inamata; Ryuichi Shirasaki Axon guidance by commissural neurons has been well documented, providing us with a molecular logic of how midline crossing is achieved during development. Despite these advances, knowledge of the intrinsic genetic programs is still limited and it remains obscure...

... that have suggested that morphogens direct axon guidance decisions using non-canonical signal transduction factors, our results indicate that canonical components of the BMP signalling pathway, the type I BMP receptors (BMPRs), are both necessary and sufficient to specify the fate of commissural neurons...

..., the dorsal root ganglia appeared reduced in size and shifted in position in embryos receiving grafts. Another dorsal cell type, commissural neurons, identified by CRABP and neurofilament immunoreactivity, differentiated in the vicinity of the ectopic notochord. Numerous neuronal cell bodies and axonal...

... interact with certain homoeobox genes whose transcripts have also been localised within the nervous system. retinoic acid retinol cellular retinoic acid‐binding protein cellular retinol-binding protein neural tube notochord motor nerves sensory nerves lamina terminalis neural crest commissural...