... investigated when and how the dendrites of the four T4/T5 subtypes acquire their specific orientations, and profiled the transcriptomes of all T4/T5 neurons during this process. This revealed a simple and stable combinatorial code of transcription factors defining the four T4/T5 subtypes during...

... © 2012. Axon guidance Transcription Combinatorial code GATA Unc-5 Drosophila Transcriptional codes within a neuron direct the expression of an array of receptors and adhesion molecules that will eventually determine its guidance and connectivity properties...

...Alain Garces; Stefan Thor During nervous system development, combinatorial codes of regulators act to specify different neuronal subclasses. However, within any given subclass,there exists a further refinement, apparent in Drosophila and C. elegans at single-cell resolution. The mechanisms that act...

...Irene Miguel-Aliaga; Douglas W. Allan; Stefan Thor In the Drosophila nerve cord, a subset of neurons expresses the neuropeptide FMRFamide related (Fmrf). Fmrf expression is controlled by a combinatorial code of intrinsic factors and an extrinsic BMP signal. However, this previously identified code...

...Sarah J. Certel; Stefan Thor In both vertebrates and invertebrates, members of the LIM-homeodomain(LIM-HD) family of transcription factors act in combinatorial codes to specify motoneuron subclass identities. In the developing Drosophila embryo,the LIM-HD factors Islet (Tailup) and Lim3, specify...

... correspond to two or three segment anlagen that fail to develop in each mutant. It has been proposed that these overlapping expression domains mediate head metamerization and could generate a combinatorial code to specify segment identity. To test this model, we developed a system for targeted gene...

... produce similar vertebral transformations, thus support-ing a combinatorial code model for specification of vertebral identity by Hox genes. * Author for correspondence † Deceased 22 11 1995 © 1996 by Company of Biologists 1996 paralogous Hox genes gene disruption...

... that functional cooperation can also occur between non-paralogous Hox gene products in axial skeleton patterning. * Author for correspondence 22 11 1995 © 1996 by Company of Biologists 1996 Hox genes gene disruption pattern formation functional redundancy combinatorial code Hoxa...