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Keywords: Cohesin
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Journal Articles
Journal: Development
Development (2021) 148 (24): dev199800.
Published: 22 December 2021
...Wei-Ting Yueh; Vijay Pratap Singh; Jennifer L. Gerton ABSTRACT Aneuploidy is frequently observed in oocytes and early embryos, begging the question of how genome integrity is monitored and preserved during this crucial period. SMC3 is a subunit of the cohesin complex that supports genome integrity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev180042.
Published: 5 October 2020
... manner. IRX3/5 associate with, promote the abundance of, and share overlapping functions with co-regulators of cell division such as the cohesin subunits SMC1, SMC3, NIPBL and CUX1. The findings imply that IRX3/5 coordinate early limb bud morphogenesis with skeletal pattern formation. * Present...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev185132.
Published: 15 May 2020
..., with a unique peri-chromosome pattern. Intriguingly, downregulation of HNRNPA3 caused chromosome disarrangement, which hindered normal separation of chromosomes during NP division, leading to mitotic delay. Furthermore, HNRNPA3 is associated with the cohesin-core subunit SMC1A and controls its association...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev166603.
Published: 1 May 2019
... on Cut knockdown. We also show that cut regulates the expression of the cohesin subunit Stromalin. Stromalin and the cohesin regulatory subunit Nipped-B are required for neuroblast death, and knockdown of Stromalin increases H3K27me3 levels in neuroblasts. Thus, Cut and cohesin regulate apoptosis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev156521.
Published: 3 January 2018
...). The nuclear architectural proteins cohesin and CCCTC-binding factor (CTCF) contribute to chromatin structure and gene regulation. We show here that normal cohesin function is important for ZGA in zebrafish. Depletion of the cohesin subunit Rad21 delays ZGA without affecting cell cycle progression. In contrast...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1648–1660.
Published: 1 May 2017
...Grace Hwang; Fengyun Sun; Marilyn O'Brien; John J. Eppig; Mary Ann Handel; Philip W. Jordan SMC complexes include three major classes: cohesin, condensin and SMC5/6. However, the localization pattern and genetic requirements for the SMC5/6 complex during mammalian oogenesis have not previously been...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (7): 1287–1292.
Published: 1 April 2015
...: incomplete release of cohesin at interkinesis after meiosis I and histone replacement during spermiogenesis. In the mutant testis, secondary spermatocytes at interkinesis accumulated and cohesin was not released normally, suggesting that the retained cohesion of sister chromatids delayed the subsequent entry...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3297–3302.
Published: 15 August 2013
... Cohesin Promoter choice Single cell diversity Homophilic interaction Self-avoidance Protocadherins (Pcdhs), which are predominantly expressed in the nervous system, constitute the largest subfamily of the cadherin superfamily of cell-adhesion molecules. The founding members...
Journal Articles
Journal: Development
Development (2012) 139 (22): 4172–4179.
Published: 15 November 2012
...Melissa D. Cunningham; Maria Gause; Yuzhong Cheng; Amanda Noyes; Dale Dorsett; James A. Kennison; Judith A Kassis Wapl protein regulates binding of the cohesin complex to chromosomes during interphase and helps remove cohesin from chromosomes at mitosis. We isolated a dominant mutation in wapl...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (6): 1045–1057.
Published: 15 March 2012
...-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells . Proc. Natl. Acad. Sci. USA 108 , 9556 – 9571 . Delgado-Olguin P. , Brand-Arzamendi K. , Scott I. C. , Jungblut B. , Stainier D. Y...
Journal Articles
Journal: Development
Development (2007) 134 (14): 2639–2649.
Published: 15 July 2007
... expression leads to cancers and developmental disorders. We conducted a forward genetic screen in zebrafish for positive regulators of runx1 that yielded the cohesin subunit rad21 . Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 and lose hematopoietic runx1 expression...
Includes: Supplementary data