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Keywords: Coco
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Journal Articles
Journal: Development
Development (2015) 142 (19): 3294–3306.
Published: 1 October 2015
... an S-cone default pathway. We report here that Coco ( Dand5 ), a member of the Cerberus gene family, is expressed in the developing and adult mouse retina. Upon exposure to recombinant COCO, human embryonic stem cells (hESCs) differentiated into S-cone photoreceptors, developed an inner segment-like...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2678–2685.
Published: 1 August 2015
... between ligands and receptors. In an unbiased, genome-wide RNAi screen to identify genes involved in ligand-dependent signaling, we unexpectedly identified the BMP/Activin/Nodal inhibitor Coco as an enhancer of TGFβ1 signaling. Coco synergizes with TGFβ1 in both cell culture and Xenopus explants...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4177–4181.
Published: 15 October 2013
... Growth Factor β (TGFβ) family influence all three germ layers; the ligands are required to induce endoderm and mesoderm, whereas inhibitors are required for formation of the ectoderm. Here, we demonstrate a vital role for maternal Coco, a secreted antagonist of TGFβ signalling, in this process. We show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (7): 1381–1389.
Published: 1 April 2003
... of this embryological activity, we have renamed this clone Coco, after the Spanish word meaning head. Current models for neural induction propose that the initial specification of the neural territory takes place during gastrulation following a local inhibition of BMP signaling in the dorsal ectoderm overlaying...