... for repression. We show further that LST-1 must partner with a PUF to associate physically with the CCR4-Not (CNOT) complex Based on these findings, we propose that the LST-1–PUF partnership is responsible for multiple molecular interactions that together form a stable effector complex on PUF target RNAs...

... plays a crucial role in liver functional maturation. The Cnot3 gene encodes an essential subunit of the Cnot complex. Mice lacking Cnot3 in liver have reduced body and liver masses, and they display anemia and severe liver damage. Histological analyses indicate that Cnot3 -deficient (Cnot3...