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Keywords: Clonal analysis
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Journal Articles
Journal: Development
Development (2023) 150 (3): dev201206.
Published: 3 February 2023
... tracing and local gene ablation using cell-permeant Cre recombinase (TAT-Cre) microinjection. First, we map the fate of undifferentiated progenitors to the different heart chambers. Then, we achieve single-cell recombination by titrating the dose of TAT-Cre, which allows clonal analysis of nascent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev193565.
Published: 15 April 2021
..., including the H2B-RFP-encoding retrovirus used in this experiment. Because the RIA-H2B-RFP was diluted at a volumetric ratio of 1:10, the resulting titer of the injected virus was 10 6 pfu/ml. In our previous work in which we performed clonal analysis on the trunk neural crest ( Tang et al., 2019 ), we had...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (20): dev193193.
Published: 23 October 2020
... studies, and how clonal analysis can be applied to questions regarding multipotency. We also highlight how effective progenitor cell tracing, when combined with recently developed molecular and imaging tools, such as single-cell transcriptomics, single-molecule fluorescence in situ hybridization and high...
Journal Articles
Journal: Development
Development (2019) 146 (1): dev170969.
Published: 4 January 2019
... of experimental settings, for example to modulate clone frequency with existing tools in established model organisms and to introduce clonal analysis in emerging experimental models. We were particularly interested to determine whether we could induce flip-outs as early as in late blastoderm or early germband...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev157222.
Published: 2 July 2018
... from a simple bilayer into a multilayered embryo enveloped by its extra-embryonic membranes. Impaired development of the amnion, the innermost membrane, causes major malformations. To clarify the origin of the mouse amnion, we used single-cell labelling and clonal analysis. We identified four clone...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2889–2895.
Published: 15 August 2017
... is restricted to the joints of uninjured fins but contributes more broadly during regeneration. Clonal analysis Fin regeneration Regeneration Zebrafish National Science Foundation 10.13039/501100008982 DGF 1106401 National Institutes of Health 10.13039/100000002 R01 GM074057...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1688–1696.
Published: 15 May 2016
... at the cellular level. Atrium Brainbow Cardiomyocyte Clonal analysis Heart development Zebrafish The heart achieves its form through the specification, proliferation and organization of cardiac muscle cells and their supporting tissues. Congenital defects in these events are relatively common...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (7): 1099–1107.
Published: 1 April 2016
...Yinan Wan; Alexandra D. Almeida; Steffen Rulands; Naima Chalour; Leila Muresan; Yunmin Wu; Benjamin D. Simons; Jie He; William A. Harris Clonal analysis is helping us understand the dynamics of cell replacement in homeostatic adult tissues ( Simons and Clevers, 2011 ). Such an analysis, however...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2835–2846.
Published: 1 July 2013
... The authors declare no competing financial interests. 2 5 2013 © 2013. Published by The Company of Biologists Ltd 2013 Brainbow Zebrafish Clonal analysis In vivo imaging Lineage Microscopy A deeper understanding of developmental and neurobiological processes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (5): 996–1002.
Published: 1 March 2013
... for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 17 12 2012 © 2013. Published by The Company of Biologists Ltd Clonal analysis Fate determination Kit Melanocyte Regeneration Stem cell Adult...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2010) 137 (4): 569–577.
Published: 15 February 2010
.... To understand how the HF stem cells regenerate the typical anagen organization, we conducted in vivo clonal analysis of key stages of the HF cycle in mice. Unexpectedly, we found that the pool of HF stem cells contains precursors with both multipotent and restricted contributions. This implies that the lineal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (21): 3567–3574.
Published: 1 November 2009
... the importance of the niche in cell fate determination. The extrinsic cues given to the Ngn3 + cell or to its immediate precursor must be tightly regulated for the correct proportions of the different cell types to be generated within a fully functional assembled islet. The MADM clonal analysis reveals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3713–3722.
Published: 15 October 2007
... describe a general method for clonal analysis in the mouse and use it to determine the topology of clone distribution along the three limb axes. We identify a lineage restriction boundary at the limb mesenchyme dorsoventral border that is unrelated to any anatomical discontinuity, and whose lineage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 737–749.
Published: 15 February 2006
... embryo. This conclusion is based on a retrospective clonal analysis, using a nlaacZ reporter targeted to the α-cardiac actin gene. A rare intragenic recombination event results in a functional nlacZ sequence, giving rise to clones ofβ-galactosidase-positive cells. Periendothelial and vascular smooth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (22): 5033–5042.
Published: 15 November 2005
...) and ventral (V) compartments( Garcia-Bellido et al.,1973 ). We examined the expression of compartment-specific genes ( en, ci and ap ) and performed clonal analysis to define the compartmental organization in the PE. In wing discs at 55 and 72 hours AED, the boundary of en in the PE is slightly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (18): 4143–4154.
Published: 15 September 2005
... ). * Author for correspondence (e-mail: [email protected] ) 11 7 2005 ©2005. 2005 Stem cell Hair follicle Morphogenesis Cell lineage Cell behavior Clonal analysis Mouse Temporally induced clones Apoptosis Anagen Cell competition Developmental strategy The hair follicle...
Journal Articles
Journal: Development
Development (2003) 130 (20): 4955–4962.
Published: 15 October 2003
... Drosophila Hemocytes Clonal analysis Cell lineage Transplantation Blood GFP Lymph gland Macrophage Hematopoiesis The hemolymph of Drosophila contains hemocytes that either circulate freely through the body cavities or are sessile, being associated with various tissues and organs...
Journal Articles
Journal: Development
Development (2003) 130 (16): 3807–3819.
Published: 15 August 2003
... address: Unité de Biologie Moléculaire du Développement, Institut Pasteur, 25 rue du Dr Roux, Cedex 15, 75724 Paris, France 1 5 2003 © 2003. 2003 Mouse Hox genes Hoxb1 Hoxb4 Hoxb8 Gastrulation Clonal analysis AP patterning Hox genes are key players...
Journal Articles
Journal: Development
Development (2003) 130 (2): 321–330.
Published: 15 January 2003
... are present in nascent neural crest populations and that these sublineages can be distinguished by their cell type-specific expression of receptor tyrosine kinases. 8 10 2002 © 2003. 2003 Neural crest Clonal analysis Lineage TrkC C-Kit Neurogenic Melanogenic Quail Many...