...: Microfluidics, time-lapse imaging and RNA-Seq reveal that the relative pressure within the lumen of the developing mouse lung controls the rate of branching morphogenesis, smooth muscle contraction and developmental maturation. Mechanical stress Morphogenesis Clock Morphodynamics Branching...

... that an anterior limit of downstream Erk activity corresponds to the future B-5 somite boundary. Moreover, the segmentation clock is required for a stepwise posterior shift of the Erk activity boundary during each segmentation. Our results provide the first molecular evidence of the future somite boundary at B-5...

... and is involved in the positioning of segmental boundaries. In addition, FGF signaling was shown to be rhythmically activated in the PSM in response to the segmentation clock. Here, we show that conditional deletion of the FGF receptor gene Fgfr1 abolishes FGF signaling in the mouse PSM,resulting in an arrest...

... analysis laacZ Self-renewing cells Stem cell Primitive streak Presomitic mesoderm Segmentation Mouse embryo Clock Patterning A central aspect of vertebrate embryo development is the segmentation and specification of its longitudinal axis ( Keynes and Stern, 1988 ). This segmentation...

... and in isolated polar lobes that have been aged for 24 h. Thus, the activation of actin mRNAs is controlled by cytoplasmic factors that function independently of cleavage and nuclear activity. I suggest that the running of a cytoplasmic clock determines when maternal mRNAs are activated, and that this clock...