... of neuropilin 1 (Npn1) inhibits cleft formation in the developing submandibular gland (SMG) cultured ex vivo. This Npn1-dependent morphogenesis is mediated by Sema3A and Sema3C in an additive manner, and can be abolished by decreasing the expression of plexin A2 or plexin D1. VEGF, another known Npn1 ligand...

.... , Hayakawa , T. , Nogawa , H. & Nakanishi , Y. ( 1988 ). The role of interstitial collagens in cleft formation of mouse embryonic submandibular gland during initial branching . Development 103 , 259 – 267 . 10.1242/dev.103.2.259 Furthmayr , H. & Von Der Mark , K...

... shown to enhance cleft formation. In contrast, collagen fibrils were rarely found at the epithelial-mesenchymal interface of the 12-day gland cultured in the presence of Clostridial or bovine dental pulp collagenase. The findings indicated that the formation of interstitial collagen bundles is essential...

...Yasuo Nakanishi; Toshiteru Morita; Hiroyuki Nogawa ABSTRACT An X-ray irradiation method was employed to analyse the role of cell proliferation in vitro in the cleft formation of mouse embryonic submandibular epithelium at early stages. When the mid 12-day gland was exposed to 200 rad of X-rays...

... electron microscopy collagenase inhibitor bacterial collagenase mesenchymal ridges cleft formation fibrillar structures Submandibular gland branching at early morphogenetic stages of the embryo is initiated by the formation of sharp furrows in the epithelium followed by their progressive...