... result in ciliopathies, congenital human disorders affecting multiple organs. Pathogenic variants in the ciliogenesis and planar cell polarity effectors (CPLANE) genes FUZZY , INTU and WDPCP disturb ciliogenesis, causing severe ciliopathies in humans and mice. Here, we show that the loss of Fuzzy in mice...

... for myogenesis through mediating ciliogenesis. Specifically, we have identified that Wnt signaling directly regulates expression of the ciliary gene Ttll3 . Impaired ciliary disassembly leads to differentiation defects in mesenchymal cells and indirectly disrupts myogenesis through decreased expression of Dlk1...

..., localizes to ciliary axonemes and basal bodies, and is required for ciliogenesis. We also demonstrate that Dyrk1a localizes to mitotic spindles and that its inhibition leads to decreased forebrain size, abnormal cell cycle progression and cell death during brain development. These findings provide...

... . 10.1007/978-1-60761-103-5_16 Alten , L. , Schuster-Gossler , K. , Beckers , A. , Groos , S. , Ulmer , B. , Hegermann , J. , Ochs , M. and Gossler , A. ( 2012 ). Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1...

... cells and are required for normal tissue development and function. Defective cilia cause complex syndromes with multiple organ manifestations termed ciliopathies. A crucial step during ciliogenesis in multiciliated cells (MCCs) is the association of future basal bodies with the apical plasma membrane...

... , Atmin H210Q/H210Q and Dynll1 GT/GT , revealing how ATMIN and its transcriptional target dynein light chain LC8-type 1 (DYNLL1) are required for normal lung morphogenesis and ciliogenesis. Expression screening of ciliogenic genes confirmed Dynll1 to be controlled by ATMIN and further revealed moderately...

... in the Xenopus GRP ( Walentek et al., 2012 ). Besides the HH, FGF and WNT pathways, NOTCH signaling has also been heavily linked to motile cilia differentiation. In the zebrafish KV, NOTCH signaling is required for proper foxj1 expression and ciliogenesis ( Lopes et al., 2010 ), although the relationship...

...Alissa Caron; Xiaolei Xu; Xueying Lin Cilia are essential for normal development. The composition and assembly of cilia has been well characterized, but the signaling and transcriptional pathways that govern ciliogenesis remain poorly studied. Here, we report that Wnt/β-catenin signaling directly...

.... Indeed, we report that motile and primary cilia were shorter in cdc14b -deficient embryos. We also demonstrate that Cdc14B function in ciliogenesis requires its phosphatase activity and can be dissociated from its function in cell cycle control. Finally, we propose that Cdc14B plays a role...

... or experimentally regenerated. To investigate further the molecular mechanism for the regulation of tektin synthesis, tektin cDNA clones were used to assess mRNA levels during ciliogenesis, zinc-induced animalization, deciliation-induced regeneration and theophylline-induced elongation. Possibly involved...

... is formed at the time that ciliogenesis starts. This band, which we visualized with TRITC-phalloidin, is positioned at the base of the row of cilia that crosses each trochoblast. Isolated trochoblasts, as well as isolated quartets of animal micromeres (from which the trochoblasts are derived), similarly...