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Keywords: Cilia
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Journal Articles
Journal: Development
Development (2024) 151 (1): dev201819.
Published: 4 January 2024
...Mycah T. Sewell; Emilie Legué; Karel F. Liem, Jr ABSTRACT Cilia are microtubule (MT)-based organelles present on the surface of nearly all vertebrate cells. MTs are polymers of α- and β-tubulins that are each encoded by multiple, individual isotype genes. Tubulin isotype composition is thought...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (24): dev201976.
Published: 21 December 2023
... Summary: Defective centrosome biogenesis in kidney progenitors blocks their growth and causes premature differentiation, resulting in abnormal branching morphogenesis, reduced nephron formation and small kidneys that become fibrotic and cystic. Centrosome Centriole Cilia Cystic kidney disease...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (14): dev201515.
Published: 18 July 2023
... risk among proteins associated with centriolar satellites. This is particularly interesting because centriolar satellites are required for the formation of tubulin-based structures, such as centrosomes and cilia, and have been hypothesized to be sites of tubulin post-translational modification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (10): dev201411.
Published: 26 May 2023
...Hannah M. Wesselman; Ana L. Flores-Mireles; Aidan Bauer; Liming Pei; Rebecca A. Wingert ABSTRACT Cilia are essential for the ontogeny and function of many tissues, including the kidney. Here, we report that transcription factor ERRγ ortholog estrogen related receptor gamma a (Esrrγa) is essential...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2022) 149 (16): dev200833.
Published: 24 August 2022
... with an apical tuft of non-motile cilia ( Fig. 1 ) ( Marinković et al., 2020 ; Conzelmann et al., 2011 ; Verasztó et al., 2017 ; Goldberg et al., 2011 ; Garner et al., 2016 ; Gruhl, 2009 ; Page, 2002 ; Chia and Koss, 1979 ). Besides the flask-shaped apical cells, the sensory (photosensitive...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (9): dev200136.
Published: 3 May 2022
... to be dependent on cilia-driven fluid flow in the embryonic node. Planar cell polarity (PCP) signalling is crucial for patterning of nodal cilia, yet downstream effectors driving this process remain elusive. We have examined the role of the JNK gene family, a proposed downstream component of PCP signalling...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (23): dev199805.
Published: 7 December 2021
...Siyu Liu; Jintao Zhang; Zine Eddine Kherraf; Shuya Sun; Xin Zhang; Caroline Cazin; Charles Coutton; Raoudha Zouari; Shuqin Zhao; Fan Hu; Selima Fourati Ben Mustapha; Christophe Arnoult; Pierre F. Ray; Mingxi Liu ABSTRACT Defects in the structure or motility of cilia and flagella may lead to severe...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev195552.
Published: 29 April 2021
...Emily K. Ho; Tim Stearns ABSTRACT The mechanisms of vertebrate Hedgehog signaling are linked to the biology of the primary cilium, an antenna-like organelle that projects from the surface of most vertebrate cell types. Although the advantages of restricting signal transduction to cilia are often...
Journal Articles
Journal: Development
Development (2021) 148 (4): dev192443.
Published: 17 February 2021
... in zebrafish. Additionally, PKA-mediated phosphorylation of Gpr161 controls its ciliary localisation to fine-tune Hedgehog signalling activity. Hedgehog signalling Gpr161 PKA Cilia Zebrafish The Hh signalling pathway is a key regulator of cell fate specification and proliferation during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev185579.
Published: 7 August 2020
... and transducing flow during embryogenesis. Shear stress Blood Lymph Cerebrospinal fluid Cilia Mechanosensation Much effort has been made to understand how fluid flow and its accompanying physical forces affect embryonic development. The activation of the right molecular pathway at the right...
Journal Articles
Journal: Development
Development (2020) 147 (3): dev183301.
Published: 3 February 2020
.... Cilia are essential for Shh signal transduction and the ciliary phosphatidylinositol phosphatase Inpp5e is linked to Shh regulation. In the course of a forward genetic screen for recessive mouse mutants, we identified a functional null allele of inositol polyphosphate-5-phosphatase E ( Inpp5e ), ridge...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev170985.
Published: 15 August 2019
... of asymmetric and symmetric structures. This Review discusses how symmetries and asymmetries can be generated alongside each other in the embryo and then maintained during growth. Symmetry Asymmetry Nodal Left-right Limbs Somites Cilia The vast majority of animals have body plans based...
Journal Articles
Journal: Development
Development (2019) 146 (6): dev172643.
Published: 15 March 2019
...Hao Lu; Priyanka Anujan; Feng Zhou; Yiliu Zhang; Yan Ling Chong; Colin D. Bingle; Sudipto Roy ABSTRACT Motile cilia on multiciliated cells (MCCs) function in fluid clearance over epithelia. Studies with Xenopus embryos and individuals with the congenital respiratory disorder reduced generation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev167130.
Published: 30 November 2018
... of the primary mesenchyme cells, gut morphology, and cilia. These defects likely result from increased Dvl protein levels, leading to perturbation of Wnt-dependent signaling pathways and additional Dvl-mediated processes. We further demonstrated that overexpression of Dvl isoforms recapitulated some of the Dvl...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev159889.
Published: 28 November 2018
... patterning. First, WDR5 is expressed in the nuclei of monociliated cells of the LR organizer (LRO) and regulates foxj1 expression. LR defects in wdr5 morphants can be partially rescued with the addition of foxj1 . Second, WDR5 localizes to the bases of cilia. Using a mutant form of WDR5, we demonstrate...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (6): dev164236.
Published: 15 March 2018
... the transition zone (TZ). The TZ serves as a gatekeeper to control protein composition in cilia, but less is known about its role in ciliary bud formation. Here, we show that centrosomal protein Dzip1l is required for Hh signaling between Smoothened and Sufu. Dzip1l colocalizes with basal body appendage proteins...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (1): dev154500.
Published: 9 January 2018
... postnatal hydrocephalus in the progressive hydrocephal us ( prh ) mouse mutant. Ccdc39 is selectively expressed in embryonic choroid plexus and ependymal cells on the medial wall of the forebrain ventricle, and the protein is localized to the axoneme of motile cilia. The Ccdc39 prh/prh ependymal cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4684–4693.
Published: 15 December 2017
..., we show that Pontin is essential for cilia motility in both zebrafish and mouse and that Pontin and Reptin function cooperatively in this process. Zebrafish pontin mutants display phenotypes tightly associated with cilia defects, and cilia motility is lost in a number of ciliated tissues along...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1544–1553.
Published: 15 April 2017
...Daisy Xin; Kasey J. Christopher; Lewie Zeng; Yong Kong; Scott D. Weatherbee Cilia are key regulators of animal development and depend on intraflagellar transport (IFT) proteins for their formation and function, yet the roles of individual IFT proteins remain unclear. We examined the Ift56 hop mouse...
Includes: Supplementary data