... to contain all its enhancers. To investigate the importance of chromatin conformation and TAD integrity on developmental gene regulation, we have manipulated the Shh TAD – creating internal deletions, deleting CTCF sites, and deleting and inverting sequences at TAD boundaries. Chromosome conformation capture...

... of genome folding and unravel the regulatory functions of nuclear organization. Nuclear organization Chromosome conformation capture Epigenetics Microscopy Nuclear organization, the physical structure of the genome within the nuclear space, has fascinated cellular and developmental...