... unveiled a novel developmental HD phenotype: the appearance of giant multinucleated telencephalic neurons at an abundance directly proportional to CAG repeat length, generated by a chromosomal instability and failed cytokinesis over multiple rounds of DNA replication. We conclude that disrupted...

... kinase ATR prevents chromosome fragmentation during postnatal cerebellar neurogenesis in mice, suggesting that ATR dependence may be exploited for medulloblastoma therapy. Microcephaly Medulloblastoma Chromosomal instability ATR Neural progenitor DNA damage Mouse National Institute...