... activation following H2Av phosphorylation by JIL-1 leads to loosening of chromatin structure, allowing JIL-1-mediated H3S10 phosphorylation to occur. A prediction of this model is that H3S10 phosphorylation would be decreased in mutants with reduced PARP-1 activity. We examined H3S10ph levels...

... 2008. 2008 Pol II Histone H3S10 phosphorylation Transcription Chromatin structure JIL-1 kinase Protein extracts were prepared from salivary glands dissected from third instar larvae (or, in some experiments, from whole larvae) homogenized in a buffer comprising: 20 mM Tris-HCl pH 8.0...

... marks in general, but is only crucial for imprinting at distinct genomic sites. * Author for correspondence (e-mail: [email protected] ) 26 11 2004 ©2005. 2005 Chromatin structure DNA methylation Gene imprinting Lsh Imprinting is an epigenetic mechanism...

... stocks carrying heat shock reporter genes positioned 1.9 and 3.7 kb downstream of lac operator repeats. Association of lacI -HP1 with the repeats resulted in silencing of both reporter genes and correlated with a closed chromatin structure consisting of regularly spaced nucleosomes, similar...

... phenocopied the cdl-1 mutant embryos, suggesting that CDL-1 contributes to the proper expression of core histone proteins. We propose that loss-of-function of cdl-1 causes aberrant chromatin structure, which affects the cell cycle and cell death, as well as transcription of genes essential for morphogenesis...

... that potentiation of chromatin domains is a dynamic process that mediates the differentiative response by altering chromatin structure. The spermatogonial stem cell can take only one of three paths: renewal, differentiation or degradation ( Dym, 1994 ). Chromosomal replication in the earliest steps...