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Keywords: Chondrogenesis
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Journal: Development
Development (2021) 148 (23): dev199607.
Published: 2 December 2021
... and Socs2 in PDGFRβ D849V cells suggests that overgrowth in mice involves PDGFRβ D849V activating the STAT5-IGF1 axis locally in the skeleton. Our study establishes that PDGFRβ D849V causes osteopenic skeletal phenotypes that are associated with intrinsic changes in SSCs, promoting chondrogenesis over...
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Journal: Development
Development (2021) 148 (19): dev199580.
Published: 24 September 2021
..., and identify key differences in the pathways that initiate formation of the hindlimb and forelimb. Using live image analysis of murine limb mesenchyme cells undergoing chondrogenesis in micromass culture, we distinguish a series of changes in cellular behaviours and cohesiveness that are required...
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Journal: Development
Development (2017) 144 (24): 4510–4521.
Published: 15 December 2017
... of these lncRNAs, LOC102723505 , which we termed ROCR (regulator of chondrogenesis RNA), by RNA interference disrupted MSC chondrogenesis, concomitant with reduced cartilage-specific gene expression and incomplete matrix component production, indicating an important role in chondrocyte biology. Specifically, SOX9...
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Journal: Development
Development (2017) 144 (4): 601–611.
Published: 15 February 2017
... . Regeneration Retinoic acid RAR Limb Patterning Chondrogenesis Northeastern University 10.13039/501100004184 National Science Foundation 10.13039/100000001 1558017 Army Research Office 10.13039/100000183 56157-LS-MUR Urodele amphibians (salamanders...
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Journal: Development
Development (2016) 143 (24): 4608–4619.
Published: 15 December 2016
... in either chondrogenesis or in subsequent bone formation. To determine the onset of the Prmt5 cKO phenotype, we analyzed digit formation at E11.5 by in situ hybridization for Sox9 , the earliest known marker of chondrocytes ( Akiyama et al., 2005 ; Bi et al., 1999 ; Lefebvre and Smits, 2005 ; Wright...
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Journal Articles
Journal: Development
Development (2015) 142 (5): 817–831.
Published: 1 March 2015
... chondrocytes. Here, we review how multiple signaling molecules, mechanical signals and morphological cell features are integrated to activate a set of key transcription factors that determine and regulate the genetic program that induces chondrogenesis and chondrocyte differentiation. Moreover, we describe...
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Journal: Development
Development (2014) 141 (20): 3978–3987.
Published: 15 October 2014
... that SHH-mediated induction of Nkx3.2 maintains the competence of somitic cells to initiate chondrogenesis in response to subsequent BMP signals by repressing BMP-dependent induction of GATA genes. Conversely, administration of BMP signals to PSM or forced expression of GATA family members in chick PSM...
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Journal Articles
Journal: Development
Development (2014) 141 (10): 2085–2095.
Published: 15 May 2014
.... V. , Yayon A. , Deng C.-X. ( 1999 ). Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis . J. Clin. Invest. 104 , 1517 - 1525 . 10.1172/JCI6690 Contreras R. G. , Miller J. H. , Zamora M. , Gonzalez...
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Journal: Development
Development (2014) 141 (4): 867–877.
Published: 15 February 2014
... interests The authors declare no competing financial interests. 18 1 2013 20 11 2013 © 2014. Published by The Company of Biologists Ltd 2014 Ezh2 Epigenetic regulation Neural crest Chondrogenesis Osteogenesis Mouse Neural crest cells (NCCs...
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Journal: Development
Development (2011) 138 (17): 3791–3801.
Published: 1 September 2011
.... Chondrogenesis Indian hedgehog Gli transcription factors Mouse The precise regulation of chondrocyte proliferation and differentiation is crucial for normal bone growth. During endochondral bone development, growth plate chondrocyte differentiation is governed by the spatial and temporal...
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Journal: Development
Development (2010) 137 (7): 1159–1167.
Published: 1 April 2010
.... ( 2002 ). Analysis of N-cadherin function in limb mesenchymal chondrogenesis in vitro . Dev. Dyn. 225 , 195 - 204 . Ducy P. , Zhang R. , Geoffroy V. , Ridall A. , Karsenty G. ( 1997 ). Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation . Cell 89...
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Journal: Development
Development (2009) 136 (7): 1093–1104.
Published: 1 April 2009
... have determined the role of receptor Smads 1, 5 and 8 in chondrogenesis. Deletion of individual Smads results in viable and fertile mice. Combined loss of Smads 1, 5 and 8, however, results in severe chondrodysplasia. Smad1/5 CKO (cartilage-specific knockout)mutant mice are nearly identical to Smad1/5...
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Journal Articles
Journal: Development
Development (2008) 135 (13): 2215–2220.
Published: 1 July 2008
..., together with impaired chondroitin sulfation and abnormal metabolism of the chondroitin sulfate proteoglycan aggrecan. Our findings identify JAWS as a key regulator of chondrogenesis and synovial joint positioning required for the restriction of joint formation to discrete stereotyped locations...
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Journal Articles
Journal: Development
Development (2008) 135 (3): 483–491.
Published: 1 February 2008
... development Chondrogenesis The apical ectodermal ridge (AER) is a specialized ectodermal structure formed at the distal tip of the vertebrate limb bud that is essential for proximodistal (PD) patterning of the limb( Saunders, 1948 ). Surgical removal of the AER results in skeletal truncation...
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Journal Articles
Journal: Development
Development (2007) 134 (21): 3917–3928.
Published: 1 November 2007
...-depleted micromass culture cells under hypoxia provided further support for the regulatory role of HIF1αin chondrogenesis. Reduced expression of Sox9 , a key regulator of chondrocyte differentiation, followed by reduction of Sox6 , collagen type II and aggrecan in Hif1 α-depleted limbs raised...
Includes: Supplementary data
Journal Articles