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Keywords: Chondrocytes
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Journal Articles
Journal: Development
Development (2018) 145 (6): dev159244.
Published: 16 March 2018
... endochondral ossification are tightly controlled by growth factors, morphogens, hormones, and transcriptional factors that engage in crosstalk with Hippo-YAP1/TAZ signaling. Here, we generated tamoxifen-inducible, chondrocyte-specific Mob1a/b -deficient mice and show that hyperactivation of endogenous YAP1/TAZ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2280–2288.
Published: 01 June 2013
... into chondrocytes and tenocytes/ligamentocytes to form the junction between cartilage and tendon/ligament. Sox9 lineage tracing in the Scx + domain revealed that Scx + progenitors can be subdivided into two distinct populations with regard to their Sox9 expression history: Scx + / Sox9 + and Scx...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4473–4483.
Published: 01 December 2012
... (HIF1α) as a central component in a mechanism that underlies collagen hydroxylation and secretion by hypoxic cells. We show that Hif1a loss of function in growth plate chondrocytes arrests the secretion of extracellular matrix proteins, including collagen type II. Reduced collagen hydroxylation and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (3): 601–611.
Published: 01 February 2012
...Weiguang Wang; Na Lian; Yun Ma; Lingzhen Li; Richard C. Gallant; Florent Elefteriou; Xiangli Yang Atf4 is a leucine zipper-containing transcription factor that activates osteocalcin ( Ocn ) in osteoblasts and indian hedgehog ( Ihh ) in chondrocytes. The relative contribution of Atf4 in chondrocytes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1507–1519.
Published: 15 April 2011
...Daisuke Ikegami; Haruhiko Akiyama; Akira Suzuki; Takashi Nakamura; Toru Nakano; Hideki Yoshikawa; Noriyuki Tsumaki During endochondral bone formation, Sox9 expression starts in mesenchymal progenitors, continues in the round and flat chondrocyte stages at high levels, and ceases just prior to the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (23): 5541–5550.
Published: 01 December 2002
... regulation of the chondrocyte phenotype. Expression ofβ-catenin was high in prechondrogenic mesenchymal cells, but significantly decreased in differentiated chondrocytes both in vivo and in vitro. Accumulation of β-catenin by the inhibition of glycogen synthase kinase-3β with LiCl inhibited chondrogenesis by...
Journal Articles
Journal: Development
Development (1985) 85 (1): 163–175.
Published: 01 February 1985
...Shinobu Nakanishi; Edwin M. Uyeki Benzamide, an inhibitor of (ADP-ribose) transferase, augmented chondrocytic differentiation of chick limb bud mesenchymal cells in micromass cultures; the incorporation of 35 SO 4 2− into the trichloroacetic-acid-insoluble constituents of cell masses as well as the...