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Keywords: Chondrocyte proliferationClose
Development (2001) 128 (24): 5099–5108.
Published: 15 December 2001
.... In contrast to Ihh mutants ( Ihh n /Ihh n ), chondrocyte differentiation proceeds normally. However, like Ihh n /Ihh n mice, proliferation of chondrocytes is reduced by about 50%, supporting a direct role for Ihh in the regulation of chondrocyte proliferation. Moreover, by overexpressing either Ihh...
Licia Selleri, Michael J. Depew, Yakop Jacobs, Sumit K. Chanda, Kwok Y. Tsang, Kathryn S. E. Cheah, John L. R. Rubenstein, Stephen O’Gorman, Michael L. Cleary
Development (2001) 128 (18): 3543–3557.
Published: 15 September 2001
... of limbs and ribs, chondrocyte proliferation was markedly diminished and there was a notable increase of hypertrophic chondrocytes, accompanied by premature ossification of bone. The pattern of expression of genes known to regulate chondrocyte differentiation was not perturbed in Pbx1-deficient cartilage...