... remained unmineralized. Chondrocyte maturation was delayed, with fewer Indian hedgehog-expressing, prehypertrophic chondrocytes forming and a smaller hypertrophic chondrocyte zone. Later, progression out of chondrocyte hypertrophy was slowed, leading to an accumulation of COLX-expressing hypertrophic...

... development. Chondrogenesis Chondrocyte hypertrophy Growth plate Sox9 Ihh PTHrP Fgfr3 Fig. 1. The stages of endochondral bone formation in the developing mouse hindlimb. (A) Schematic representation of mesenchymal cells (blue) that begin to form condensations at E11.5 in the hindlimb...

...Satoru Sasagawa; Hiroshi Takemori; Tatsuya Uebi; Daisuke Ikegami; Kunihiko Hiramatsu; Shiro Ikegawa; Hideki Yoshikawa; Noriyuki Tsumaki Chondrocyte hypertrophy is crucial for endochondral ossification, but the mechanism underlying this process is not fully understood. We report that salt-inducible...

...Kinglun Kingston Mak; Henry M. Kronenberg; Pao-Tien Chuang; Susan Mackem; Yingzi Yang Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte hypertrophy is also required in postnatal cartilage homeostasis. Indian hedgehog (Ihh...

... inhibit chondrocyte hypertrophy and synovial joint formation independently ofβ-catenin. However, there is a strong synergistic interaction between Wnt/β-catenin and Ihh signaling in regulating synovial joint formation. * Authors for correspondence (e-mail: [email protected] ; yingzi...