... midgut constriction defects in Kah mutants similar to those of pointed ( pnt ). ChIP and RNA-Seq data analysis defined a Kah target-binding site similar to that of Snail, and identified a set of common target genes putatively regulated by Kah and Pnt during midgut constriction. Taken together, we report...

... their identification even where the cis -acting factors are known ( Junion et al., 2012 ). Direct methods of identifying CRMs using ChIP and DNase hypersensitivity approaches allow the identification of CRMs that could not be found by sequence analysis alone (e.g. Blow et al., 2010 ). However, such direct...

... into the adult eye, antenna and head cuticle. We have found that the transcriptional co-factor Chip is required for cells at the ventral eye-antennal disc border to take on a head cuticle fate; clones of Chip mutant cells in this region instead form outgrowths that differentiate into ectopic eye tissue. Chip...

...Luc Vanolst; Catherine Fromental-Ramain; Philippe Ramain The GATA factor Pannier (Pnr) activates proneural expression through binding to a remote enhancer of the achaete-scute ( ac-sc )complex. Chip associates both with Pnr and with the (Ac-Sc)-Daughterless heterodimer bound to the ac-sc promoters...

... and aristaless ( al ) are part of the gene battery required for the development of specific leg segments. Our genetic results show that there are posttranslational interactions between Ap, Bar and the LIM-domain binding protein Chip in tarsus four, and between Al, Lim1 and Chip in the pretarsus...

...Donald J. van Meyel; John B. Thomas; Alan D. Agulnick LIM-homeodomain transcription factors control a variety of developmental processes, and are assembled into functional complexes with the LIM-binding co-factor Ldb1 (in mouse) or Chip (in Drosophila ). We describe the identification...